| SP | Koufax, S.Koufax, Sandy † $ >> | 30 | 1965 | L | 97 | 27 | 27 | 13 | 9 | 3.31 | .289 | 1.20 | 7.8 | 3.0 | 8.4 | 187.1 | 163 | 74 | 69 | 23 | 62 | 175 | 5 | 0 | 0 | 1 | 21 | 3 | 4 | 3.77 |
| SP | Brown, M.Brown, Mordecai $$ >> | 32 | 1908 | R | 84 | 25 | 25 | 9 | 8 | 5.05 | .317 | 1.34 | 9.3 | 2.7 | 3.9 | 155.0 | 161 | 89 | 87 | 23 | 47 | 67 | 3 | 0 | 0 | 2 | 9 | 8 | 1 | 5.13 |
| SP | Alexander, P.Alexander, Pete † $ >> | 28 | 1915 | R | 88 | 27 | 26 | 15 | 7 | 3.78 | .279 | 1.16 | 8.0 | 2.4 | 5.3 | 173.2 | 154 | 74 | 73 | 16 | 47 | 102 | 8 | 0 | 0 | 2 | 17 | 1 | 1 | 3.86 |
| SP | Hearn, J.Hearn, Jim † $$ >> | 29 | 1950 | R | 76 | 26 | 26 | 13 | 4 | 3.42 | .298 | 1.25 | 6.9 | 4.4 | 4.9 | 160.1 | 122 | 61 | 61 | 15 | 78 | 87 | 2 | 0 | 0 | 1 | 16 | 4 | 6 | 4.67 |
| SP | Sutton, D.Sutton, Don # >> | 27 | 1972 | R | 82 | 24 | 24 | 10 | 7 | 4.35 | .292 | 1.22 | 8.9 | 2.0 | 5.8 | 159.1 | 158 | 81 | 77 | 19 | 36 | 103 | 4 | 0 | 0 | 3 | 10 | 3 | 2 | 3.99 |
| RP | Hader, J.Hader, Josh # >> | 24 | 2018 | L | 93 | 63 | 0 | 0 | 4 | 5.11 | .313 | 1.34 | 7.4 | 4.7 | 8.0 | 44.0 | 36 | 25 | 25 | 4 | 23 | 39 | 0 | 1 | 2 | 0 | 0 | 1 | 0 | 4.05 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 82 | 57 | 0 | 5 | 0 | 3.97 | .300 | 1.25 | 7.6 | 3.9 | 6.6 | 56.2 | 47 | 26 | 25 | 9 | 24 | 41 | 0 | 1 | 2 | 0 | 0 | 2 | 0 | 5.02 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 76 | 43 | 0 | 4 | 3 | 4.70 | .307 | 1.30 | 9.0 | 2.7 | 6.3 | 46.0 | 46 | 24 | 24 | 11 | 14 | 32 | 0 | 1 | 3 | 0 | 0 | 1 | 0 | 5.70 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 77 | 27 | 0 | 2 | 1 | 3.60 | .286 | 1.13 | 8.4 | 1.8 | 7.8 | 30.0 | 28 | 12 | 12 | 7 | 6 | 26 | 0 | 2 | 3 | 0 | 0 | 2 | 0 | 5.10 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 74 | 22 | 0 | 0 | 1 | 3.32 | .369 | 1.71 | 9.9 | 6.0 | 8.6 | 21.2 | 23 | 8 | 8 | 2 | 14 | 20 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 4.48 |
| CL | Jansen, K.Jansen, Kenley † >> | 28 | 2016 | R | 97 | 48 | 0 | 1 | 6 | 3.35 | .275 | 1.14 | 7.9 | 2.3 | 8.6 | 51.0 | 45 | 19 | 19 | 6 | 13 | 49 | 0 | 30 | 3 | 0 | 0 | 0 | 3 | 3.37 |