| SP | Johnson, W.Johnson, Walter >> | 26 | 1913 | R | 95 | 27 | 27 | 10 | 13 | 4.67 | .284 | 1.18 | 8.5 | 2.2 | 4.9 | 183.0 | 172 | 96 | 95 | 24 | 44 | 99 | 8 | 0 | 0 | 2 | 12 | 2 | 5 | 4.38 |
| SP | Leonard, D.Leonard, Dutch >> | 22 | 1914 | L | 91 | 26 | 26 | 14 | 8 | 2.97 | .271 | 1.07 | 6.2 | 3.4 | 5.0 | 176.0 | 121 | 60 | 58 | 16 | 67 | 97 | 1 | 0 | 0 | 1 | 19 | 8 | 3 | 4.36 |
| SP | Maddux, G.Maddux, Greg # >> | 29 | 1995 | R | 89 | 26 | 26 | 12 | 9 | 4.30 | .281 | 1.14 | 8.3 | 1.9 | 5.4 | 184.0 | 170 | 94 | 88 | 17 | 39 | 110 | 13 | 0 | 0 | 1 | 14 | 7 | 5 | 3.76 |
| SP | Santana, J.Santana, Johan # >> | 25 | 2004 | L | 85 | 25 | 25 | 8 | 8 | 5.60 | .304 | 1.30 | 8.1 | 3.6 | 8.5 | 146.1 | 131 | 93 | 91 | 27 | 59 | 138 | 1 | 0 | 0 | 0 | 11 | 2 | 4 | 4.77 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 64 | 0 | 6 | 3 | 3.17 | .276 | 1.12 | 7.9 | 2.2 | 7.5 | 82.1 | 72 | 29 | 29 | 4 | 20 | 68 | 0 | 6 | 3 | 0 | 0 | 2 | 4 | 2.78 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 42 | 0 | 4 | 2 | 3.54 | .286 | 1.20 | 6.6 | 4.3 | 12.2 | 48.1 | 35 | 21 | 19 | 9 | 23 | 65 | 0 | 5 | 4 | 0 | 0 | 0 | 0 | 4.17 |
| RP | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 78 | 17 | 0 | 1 | 0 | 0.00 | .169 | 0.61 | 4.0 | 1.5 | 10.5 | 18.0 | 8 | 1 | 0 | 0 | 3 | 21 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 1.17 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 73 | 19 | 0 | 1 | 0 | 1.61 | .295 | 1.21 | 5.7 | 5.3 | 6.1 | 22.1 | 14 | 4 | 4 | 0 | 13 | 15 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 3.55 |
| SP | Marichal, J.Marichal, Juan >> | 29 | 1966 | R | 77 | 17 | 0 | 2 | 3 | 5.44 | .321 | 1.41 | 9.4 | 3.2 | 6.0 | 81.0 | 85 | 50 | 49 | 11 | 29 | 54 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.54 |