| SP | Kershaw, C.Kershaw, Clayton † # >> | 28 | 2016 | L | 99 | 18 | 18 | 12 | 5 | 3.09 | .271 | 1.08 | 7.6 | 2.1 | 7.8 | 137.0 | 116 | 50 | 47 | 9 | 32 | 118 | 4 | 0 | 0 | 1 | 12 | 5 | 3 | 2.94 |
| SP | Leonard, D.Leonard, Dutch >> | 22 | 1914 | L | 91 | 17 | 17 | 6 | 6 | 4.22 | .313 | 1.36 | 8.1 | 4.2 | 5.5 | 106.2 | 95 | 52 | 50 | 11 | 50 | 65 | 0 | 0 | 0 | 0 | 11 | 1 | 2 | 4.57 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 17 | 17 | 9 | 6 | 4.54 | .304 | 1.29 | 8.2 | 3.4 | 9.0 | 113.0 | 103 | 59 | 57 | 13 | 43 | 113 | 3 | 0 | 0 | 1 | 10 | 2 | 2 | 3.69 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 76 | 17 | 17 | 7 | 7 | 5.00 | .317 | 1.39 | 8.4 | 4.2 | 7.4 | 102.2 | 95 | 58 | 57 | 12 | 48 | 84 | 0 | 0 | 0 | 0 | 9 | 0 | 1 | 4.29 |
| RP | Uehara, K.Uehara, Koji † >> | 38 | 2013 | R | 100 | 52 | 0 | 4 | 2 | 3.06 | .231 | 0.86 | 6.3 | 1.5 | 7.4 | 67.2 | 47 | 23 | 23 | 7 | 11 | 55 | 0 | 7 | 3 | 0 | 0 | 3 | 0 | 3.34 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 31 | 0 | 3 | 1 | 1.40 | .201 | 0.73 | 6.0 | 0.6 | 8.2 | 45.0 | 30 | 7 | 7 | 2 | 3 | 41 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 2.02 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 23 | 0 | 3 | 1 | 2.17 | .243 | 0.97 | 5.3 | 3.4 | 7.8 | 29.0 | 17 | 7 | 7 | 3 | 11 | 25 | 0 | 6 | 1 | 0 | 0 | 0 | 0 | 3.76 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 85 | 17 | 0 | 0 | 1 | 2.53 | .281 | 1.13 | 7.3 | 3.0 | 8.6 | 21.1 | 17 | 6 | 6 | 1 | 7 | 20 | 0 | 3 | 0 | 0 | 0 | 1 | 0 | 2.86 |
| RP | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 77 | 18 | 0 | 0 | 0 | 5.66 | .361 | 1.65 | 9.0 | 6.3 | 9.0 | 20.2 | 20 | 14 | 13 | 3 | 14 | 20 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 5.20 |