| SP | Koufax, S.Koufax, Sandy >> | 30 | 1965 | L | 98 | 9 | 9 | 4 | 4 | 4.61 | .295 | 1.24 | 7.4 | 3.9 | 7.9 | 56.2 | 46 | 31 | 29 | 6 | 24 | 49 | 2 | 0 | 0 | 0 | 4 | 1 | 1 | 3.98 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 8 | 8 | 2 | 4 | 2.79 | .320 | 1.39 | 9.2 | 3.5 | 4.9 | 51.2 | 52 | 26 | 16 | 7 | 20 | 28 | 1 | 0 | 0 | 1 | 6 | 1 | 1 | 4.92 |
| SP | Hudson, D.Hudson, Daniel # >> | 23 | 2010 | R | 60 | 8 | 8 | 3 | 2 | 5.31 | .321 | 1.39 | 10.7 | 1.9 | 6.4 | 42.1 | 50 | 28 | 25 | 6 | 9 | 30 | 0 | 0 | 0 | 0 | 4 | 1 | 1 | 4.14 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 84 | 20 | 0 | 0 | 1 | 1.71 | .248 | 0.99 | 8.7 | 0.3 | 6.6 | 26.1 | 25 | 6 | 5 | 2 | 1 | 19 | 0 | 3 | 1 | 0 | 0 | 0 | 0 | 2.65 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 68 | 17 | 0 | 1 | 1 | 2.05 | .320 | 1.36 | 7.8 | 4.5 | 3.3 | 22.0 | 19 | 6 | 5 | 3 | 11 | 8 | 0 | 2 | 1 | 0 | 0 | 1 | 0 | 5.68 |
| RP | Foulke, K.Foulke, Keith >> | 27 | 1999 | R | 59 | 13 | 0 | 1 | 3 | 5.27 | .339 | 1.54 | 10.4 | 4.2 | 7.6 | 13.2 | 15 | 8 | 8 | 3 | 6 | 11 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 5.69 |
| SP | Drysdale, D.Drysdale, Don >> | 28 | 1964 | R | 59 | 2 | 0 | 0 | 0 | 2.25 | .368 | 1.75 | 11.3 | 4.5 | 6.8 | 4.0 | 5 | 1 | 1 | 1 | 2 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6.25 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 58 | 7 | 0 | 1 | 1 | 4.05 | .273 | 1.13 | 6.9 | 3.5 | 4.8 | 13.1 | 10 | 8 | 6 | 1 | 5 | 7 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 4.08 |