| SP | Koufax, S.Koufax, Sandy † >> | 30 | 1965 | L | 97 | 36 | 36 | 16 | 11 | 3.56 | .286 | 1.18 | 7.7 | 3.0 | 8.2 | 252.2 | 215 | 106 | 100 | 30 | 84 | 229 | 7 | 0 | 0 | 2 | 20 | 5 | 2 | 3.79 |
| SP | Alexander, P.Alexander, Pete >> | 28 | 1915 | R | 88 | 35 | 35 | 17 | 14 | 4.14 | .294 | 1.23 | 8.2 | 3.0 | 4.7 | 223.2 | 202 | 105 | 103 | 17 | 74 | 117 | 7 | 0 | 0 | 3 | 14 | 3 | 4 | 3.98 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 83 | 86 | 0 | 3 | 4 | 5.84 | .323 | 1.42 | 7.8 | 4.9 | 8.4 | 91.0 | 79 | 63 | 59 | 12 | 50 | 85 | 0 | 2 | 5 | 0 | 0 | 1 | 1 | 4.53 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 81 | 62 | 0 | 2 | 0 | 3.94 | .311 | 1.31 | 7.7 | 4.2 | 7.6 | 75.1 | 64 | 39 | 33 | 6 | 35 | 63 | 0 | 2 | 2 | 0 | 0 | 3 | 0 | 3.88 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 77 | 55 | 0 | 3 | 4 | 4.08 | .304 | 1.30 | 9.4 | 2.3 | 9.0 | 64.0 | 67 | 30 | 29 | 10 | 16 | 64 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 3.83 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 44 | 0 | 0 | 2 | 2.74 | .274 | 1.09 | 4.7 | 5.1 | 9.6 | 46.0 | 24 | 14 | 14 | 3 | 26 | 49 | 0 | 0 | 0 | 0 | 0 | 2 | 3 | 3.54 |
| RP | Eckersley, D.Eckersley, Dennis $ >> | 36 | 1990 | R | 88 | 46 | 0 | 2 | 0 | 2.52 | .289 | 1.19 | 8.4 | 2.4 | 7.7 | 60.2 | 56 | 20 | 17 | 4 | 16 | 51 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 3.07 |
| SU | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 58 | 0 | 3 | 1 | 3.68 | .307 | 1.26 | 8.8 | 2.6 | 7.3 | 58.2 | 57 | 25 | 24 | 8 | 17 | 47 | 0 | 7 | 5 | 0 | 0 | 4 | 0 | 4.26 |
| CL | Wagner, B.Wagner, Billy † >> | 28 | 1999 | L | 95 | 65 | 0 | 4 | 6 | 3.04 | .306 | 1.31 | 6.6 | 5.2 | 10.6 | 68.0 | 50 | 24 | 23 | 4 | 39 | 80 | 0 | 36 | 5 | 0 | 0 | 1 | 1 | 3.18 |