| SP | Verlander, J.Verlander, Justin >> | 36 | 2019 | R | 99 | 22 | 22 | 7 | 8 | 4.42 | .309 | 1.30 | 9.0 | 2.7 | 7.7 | 152.2 | 152 | 76 | 75 | 31 | 46 | 130 | 3 | 0 | 0 | 1 | 12 | 7 | 3 | 4.99 |
| SP | Mathewson, C.Mathewson, Christy † >> | 28 | 1908 | R | 83 | 21 | 21 | 13 | 5 | 2.03 | .240 | 0.93 | 6.6 | 1.8 | 4.6 | 172.2 | 126 | 45 | 39 | 12 | 34 | 87 | 8 | 0 | 0 | 1 | 19 | 4 | 2 | 3.56 |
| SP | Bender, C.Bender, Chief # >> | 26 | 1910 | R | 72 | 20 | 20 | 7 | 10 | 4.56 | .306 | 1.28 | 8.9 | 2.6 | 4.9 | 162.0 | 161 | 83 | 82 | 19 | 47 | 88 | 8 | 0 | 0 | 1 | 7 | 6 | 1 | 4.42 |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 67 | 20 | 20 | 6 | 12 | 5.07 | .332 | 1.47 | 9.7 | 3.6 | 6.9 | 136.2 | 147 | 80 | 77 | 21 | 54 | 105 | 3 | 0 | 0 | 3 | 7 | 3 | 3 | 4.72 |
| SP | Drysdale, D.Drysdale, Don >> | 28 | 1964 | R | 59 | 20 | 20 | 4 | 13 | 7.14 | .370 | 1.70 | 10.9 | 4.4 | 4.8 | 122.1 | 148 | 101 | 97 | 13 | 60 | 65 | 5 | 0 | 0 | 0 | 8 | 8 | 7 | 4.99 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 49 | 0 | 3 | 3 | 3.34 | .276 | 1.13 | 8.1 | 2.0 | 7.8 | 62.0 | 56 | 25 | 23 | 6 | 14 | 54 | 0 | 4 | 2 | 0 | 0 | 1 | 0 | 3.24 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 76 | 41 | 0 | 1 | 0 | 3.05 | .315 | 1.35 | 8.8 | 3.5 | 8.3 | 41.1 | 40 | 14 | 14 | 2 | 16 | 38 | 0 | 4 | 0 | 0 | 0 | 1 | 3 | 3.02 |
| RP | Urbina, U.Urbina, Ugueth >> | 24 | 1998 | R | 59 | 22 | 0 | 2 | 2 | 4.18 | .324 | 1.35 | 7.0 | 5.5 | 6.7 | 23.2 | 18 | 12 | 11 | 4 | 14 | 17 | 0 | 2 | 0 | 0 | 0 | 2 | 0 | 5.87 |
| SP | Chance, D.Chance, Dean >> | 23 | 1964 | R | 53 | 6 | 0 | 1 | 1 | 1.08 | .219 | 0.84 | 5.6 | 2.3 | 5.6 | 8.1 | 5 | 1 | 1 | 1 | 2 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.13 |