| SP | Koufax, S.Koufax, Sandy † $ >> | 30 | 1965 | L | 97 | 22 | 22 | 12 | 6 | 3.49 | .279 | 1.13 | 7.3 | 2.9 | 8.6 | 167.2 | 136 | 65 | 65 | 17 | 54 | 160 | 7 | 0 | 0 | 4 | 15 | 5 | 2 | 3.47 |
| SP | Leonard, D.Leonard, Dutch >> | 22 | 1914 | L | 91 | 21 | 21 | 10 | 7 | 3.45 | .311 | 1.33 | 7.7 | 4.3 | 5.0 | 141.0 | 120 | 59 | 54 | 9 | 67 | 79 | 1 | 0 | 0 | 0 | 13 | 4 | 1 | 4.22 |
| SP | Brown, M.Brown, Mordecai >> | 32 | 1908 | R | 85 | 20 | 20 | 9 | 10 | 4.41 | .320 | 1.40 | 9.2 | 3.4 | 4.0 | 145.0 | 148 | 76 | 71 | 14 | 55 | 65 | 3 | 0 | 0 | 0 | 12 | 2 | 2 | 4.54 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 76 | 20 | 20 | 5 | 9 | 5.76 | .324 | 1.42 | 8.1 | 4.8 | 7.1 | 118.2 | 106 | 77 | 76 | 16 | 63 | 93 | 0 | 0 | 0 | 0 | 7 | 2 | 1 | 4.84 |
| SP | Chesbro, J.Chesbro, Jack >> | 30 | 1904 | R | 65 | 20 | 20 | 9 | 9 | 4.62 | .318 | 1.37 | 9.2 | 3.1 | 4.3 | 150.0 | 154 | 81 | 77 | 13 | 51 | 72 | 3 | 0 | 0 | 0 | 10 | 5 | 6 | 4.29 |
| CL | Uehara, K.Uehara, Koji † >> | 38 | 2013 | R | 100 | 34 | 0 | 0 | 1 | 3.82 | .270 | 1.08 | 6.9 | 3.0 | 7.5 | 30.2 | 23 | 13 | 13 | 3 | 10 | 25 | 0 | 26 | 3 | 0 | 0 | 1 | 0 | 3.73 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 84 | 40 | 0 | 2 | 1 | 2.01 | .253 | 1.02 | 5.6 | 3.6 | 7.0 | 40.1 | 25 | 9 | 9 | 0 | 16 | 31 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.65 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 82 | 25 | 0 | 4 | 2 | 4.00 | .264 | 1.04 | 6.0 | 3.3 | 4.7 | 27.0 | 18 | 12 | 12 | 4 | 10 | 14 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 5.11 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 82 | 20 | 0 | 1 | 0 | 3.75 | .242 | 0.96 | 6.0 | 2.6 | 9.4 | 24.0 | 16 | 10 | 10 | 2 | 7 | 25 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.88 |
| RP | Benoit, J.Benoit, Joaquin >> | 33 | 2010 | R | 95 | 21 | 0 | 0 | 1 | 4.61 | .311 | 1.35 | 7.7 | 4.7 | 7.3 | 27.1 | 23 | 14 | 14 | 3 | 14 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.37 |