| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 90 | 21 | 21 | 11 | 2 | 3.81 | .304 | 1.31 | 10.0 | 1.8 | 5.7 | 151.1 | 168 | 66 | 64 | 20 | 30 | 95 | 2 | 0 | 0 | 0 | 12 | 0 | 6 | 4.06 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 83 | 20 | 20 | 7 | 5 | 4.02 | .299 | 1.24 | 8.1 | 3.1 | 8.6 | 125.1 | 113 | 58 | 56 | 16 | 43 | 120 | 0 | 0 | 0 | 0 | 10 | 4 | 1 | 3.87 |
| SP | Harvey, M.Harvey, Matt >> | 24 | 2013 | R | 77 | 20 | 20 | 9 | 5 | 4.12 | .291 | 1.22 | 8.2 | 2.7 | 8.0 | 131.0 | 120 | 61 | 60 | 19 | 40 | 117 | 1 | 0 | 0 | 0 | 13 | 1 | 4 | 4.04 |
| SP | Schilling, C.Schilling, Curt # >> | 36 | 2002 | R | 65 | 14 | 8 | 3 | 5 | 4.83 | .294 | 1.24 | 9.0 | 2.2 | 8.5 | 78.1 | 78 | 42 | 42 | 14 | 19 | 74 | 0 | 0 | 0 | 0 | 3 | 1 | 0 | 4.21 |
| RP | Kuo, H.Kuo, Hong-Chih † >> | 29 | 2010 | L | 89 | 46 | 0 | 5 | 3 | 2.47 | .268 | 1.08 | 5.7 | 4.2 | 10.2 | 54.2 | 34 | 15 | 15 | 5 | 25 | 61 | 0 | 10 | 3 | 0 | 0 | 1 | 0 | 3.39 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 90 | 38 | 0 | 6 | 5 | 3.50 | .268 | 1.08 | 7.6 | 2.2 | 9.2 | 46.1 | 39 | 18 | 18 | 9 | 11 | 47 | 0 | 6 | 1 | 0 | 0 | 1 | 0 | 4.28 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 75 | 24 | 0 | 4 | 0 | 1.82 | .275 | 1.14 | 3.8 | 6.8 | 10.5 | 24.2 | 10 | 6 | 5 | 3 | 18 | 28 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 4.54 |
| RP | Chapman, A.Chapman, Aroldis >> | 37 | 2025 | L | 96 | 49 | 0 | 2 | 1 | 3.70 | .309 | 1.34 | 8.2 | 4.0 | 9.8 | 65.2 | 59 | 27 | 27 | 7 | 29 | 71 | 0 | 7 | 4 | 0 | 0 | 0 | 5 | 3.55 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 70 | 16 | 0 | 3 | 2 | 2.12 | .215 | 0.82 | 5.3 | 2.1 | 12.7 | 17.0 | 10 | 4 | 4 | 1 | 4 | 24 | 0 | 3 | 0 | 0 | 0 | 0 | 1 | 1.65 |
| RP | Saucier, K.Saucier, Kevin >> | 25 | 1981 | L | 55 | 16 | 0 | 0 | 0 | 5.03 | .263 | 1.07 | 3.3 | 6.6 | 5.2 | 19.2 | 7 | 11 | 11 | 1 | 14 | 11 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 4.74 |