| SP | Snell, B.Snell, Blake † >> | 25 | 2018 | L | 88 | 25 | 25 | 10 | 7 | 4.00 | .310 | 1.33 | 8.0 | 4.0 | 9.1 | 146.1 | 130 | 71 | 65 | 24 | 65 | 148 | 0 | 0 | 0 | 0 | 12 | 2 | 3 | 4.49 |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 78 | 23 | 23 | 9 | 9 | 4.14 | .319 | 1.38 | 8.4 | 4.0 | 8.8 | 158.2 | 148 | 78 | 73 | 18 | 71 | 154 | 1 | 0 | 0 | 0 | 13 | 4 | 5 | 3.96 |
| SP | Gooden, D.Gooden, Dwight >> | 21 | 1985 | R | 76 | 22 | 22 | 7 | 8 | 4.58 | .306 | 1.28 | 8.3 | 3.3 | 6.2 | 147.1 | 135 | 79 | 75 | 25 | 54 | 101 | 2 | 0 | 0 | 0 | 12 | 6 | 2 | 5.06 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 91 | 65 | 0 | 3 | 2 | 2.75 | .264 | 1.03 | 5.7 | 3.7 | 9.1 | 68.2 | 43 | 22 | 21 | 4 | 28 | 69 | 0 | 4 | 1 | 0 | 0 | 3 | 0 | 3.10 |
| RP | Bautista, F.Bautista, Félix # >> | 28 | 2023 | R | 73 | 43 | 0 | 5 | 3 | 4.46 | .303 | 1.28 | 9.2 | 2.4 | 9.0 | 38.1 | 39 | 19 | 19 | 6 | 10 | 38 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 3.92 |
| CL | Urbina, U.Urbina, Ugueth † >> | 24 | 1998 | R | 56 | 38 | 0 | 6 | 1 | 1.13 | .167 | 0.60 | 2.5 | 2.9 | 9.9 | 40.0 | 11 | 5 | 5 | 1 | 13 | 44 | 0 | 15 | 0 | 0 | 0 | 0 | 2 | 2.10 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 75 | 22 | 0 | 0 | 4 | 4.37 | .306 | 1.28 | 7.0 | 4.9 | 8.2 | 22.2 | 17 | 12 | 11 | 5 | 12 | 20 | 0 | 1 | 2 | 0 | 0 | 1 | 1 | 5.91 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 70 | 23 | 0 | 1 | 3 | 5.48 | .355 | 1.65 | 7.8 | 7.0 | 9.0 | 23.0 | 20 | 15 | 14 | 1 | 18 | 23 | 0 | 7 | 3 | 0 | 0 | 0 | 1 | 3.91 |
| RP | Harvey, B.Harvey, Bryan >> | 28 | 1991 | R | 64 | 11 | 0 | 2 | 0 | 2.84 | .240 | 0.95 | 9.0 | 0.0 | 11.3 | 12.2 | 12 | 4 | 4 | 2 | 0 | 15 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 2.67 |
| RP | Perkins, G.Perkins, Glen # >> | 30 | 2013 | L | 46 | 61 | 0 | 1 | 3 | 5.58 | .342 | 1.51 | 8.8 | 5.0 | 7.9 | 40.1 | 39 | 25 | 25 | 9 | 22 | 35 | 0 | 1 | 2 | 0 | 0 | 2 | 0 | 5.98 |