| SP | Arrieta, J.Arrieta, Jake † >> | 29 | 2015 | R | 99 | 17 | 17 | 10 | 4 | 3.08 | .270 | 1.10 | 7.5 | 2.5 | 8.4 | 117.0 | 97 | 41 | 40 | 14 | 32 | 109 | 4 | 0 | 0 | 3 | 13 | 1 | 0 | 3.54 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 88 | 17 | 17 | 0 | 2 | 2.66 | .279 | 1.16 | 5.5 | 4.9 | 9.2 | 44.0 | 27 | 16 | 13 | 2 | 24 | 45 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.18 |
| SP | Darvish, Y.Darvish, Yu >> | 33 | 2020 | R | 76 | 18 | 18 | 0 | 1 | 4.14 | .272 | 1.08 | 7.4 | 2.3 | 7.4 | 50.0 | 41 | 24 | 23 | 7 | 13 | 41 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 4.08 |
| SP | Brown, M.Brown, Mordecai >> | 31 | 1907 | R | 73 | 18 | 17 | 9 | 5 | 3.75 | .295 | 1.25 | 8.8 | 2.4 | 5.1 | 103.1 | 101 | 52 | 43 | 7 | 28 | 58 | 1 | 0 | 0 | 1 | 9 | 1 | 1 | 3.60 |
| SP | Taylor, J.Taylor, Jack >> | 32 | 1906 | R | 62 | 17 | 17 | 8 | 4 | 5.01 | .344 | 1.57 | 10.3 | 3.8 | 4.4 | 106.0 | 121 | 70 | 59 | 12 | 45 | 52 | 1 | 0 | 0 | 1 | 7 | 1 | 0 | 4.79 |
| RP | Kimbrel, C.Kimbrel, Craig † >> | 33 | 2021 | R | 100 | 51 | 0 | 8 | 0 | 2.77 | .283 | 1.15 | 5.1 | 5.3 | 11.1 | 65.0 | 37 | 22 | 20 | 7 | 38 | 80 | 0 | 4 | 1 | 0 | 0 | 2 | 4 | 3.78 |
| RP | Edwards, C.Edwards, Carl >> | 24 | 2016 | R | 98 | 43 | 0 | 2 | 1 | 3.73 | .306 | 1.30 | 6.1 | 5.8 | 12.1 | 50.2 | 34 | 26 | 21 | 6 | 32 | 67 | 0 | 4 | 1 | 0 | 0 | 1 | 5 | 3.86 |
| RP | Tepera, R.Tepera, Ryan >> | 33 | 2021 | R | 97 | 33 | 0 | 5 | 1 | 6.33 | .323 | 1.43 | 8.6 | 4.5 | 10.1 | 42.2 | 40 | 30 | 30 | 6 | 21 | 47 | 0 | 1 | 2 | 0 | 0 | 0 | 4 | 4.12 |
| RP | Marmol, C.Marmol, Carlos # >> | 25 | 2007 | R | 59 | 39 | 0 | 1 | 0 | 2.98 | .284 | 1.19 | 6.5 | 4.2 | 10.2 | 51.1 | 37 | 17 | 17 | 6 | 24 | 58 | 0 | 4 | 1 | 0 | 0 | 0 | 1 | 3.67 |
| RP | Weaver, H.Weaver, Harry >> | 26 | 1918 | R | 35 | 28 | 0 | 4 | 3 | 2.72 | .265 | 1.04 | 7.2 | 2.2 | 4.1 | 46.1 | 37 | 14 | 14 | 2 | 11 | 21 | 0 | 1 | 2 | 0 | 0 | 2 | 0 | 3.50 |
| RP | Leclerc, J.Leclerc, Jose >> | 23 | 2017 | R | 49 | 2 | 0 | 1 | 0 | 4.50 | .400 | 2.00 | 9.0 | 9.0 | 13.5 | 2.0 | 2 | 1 | 1 | 0 | 2 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3.00 |
| RP | Chavez, J.Chavez, Jesse >> | 35 | 2018 | R | 83 | 36 | 0 | 4 | 2 | 6.26 | .381 | 1.80 | 13.4 | 3.1 | 8.8 | 41.2 | 61 | 32 | 29 | 6 | 14 | 40 | 0 | 5 | 1 | 0 | 0 | 2 | 0 | 4.12 |
| RP | Rosenthal, T.Rosenthal, Trevor >> | 27 | 2017 | R | 36 | 2 | 0 | 0 | 0 | 0.00 | .222 | 0.86 | 9.0 | 0.0 | 13.5 | 2.1 | 2 | 0 | 0 | 0 | 0 | 3 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0.00 |