| SP | Santana, J.Santana, Johan # >> | 28 | 2007 | L | 98 | 36 | 36 | 12 | 14 | 3.65 | .278 | 1.12 | 8.1 | 1.9 | 9.2 | 222.0 | 201 | 92 | 90 | 23 | 48 | 228 | 1 | 0 | 0 | 0 | 22 | 8 | 4 | 3.05 |
| SP | Lackey, J.Lackey, John >> | 29 | 2007 | R | 72 | 33 | 33 | 13 | 10 | 4.90 | .335 | 1.48 | 10.3 | 3.0 | 7.0 | 189.1 | 217 | 108 | 103 | 28 | 64 | 146 | 1 | 0 | 0 | 1 | 17 | 5 | 1 | 4.48 |
| SP | Schilling, C.Schilling, Curt >> | 41 | 2007 | R | 50 | 32 | 31 | 13 | 11 | 4.31 | .329 | 1.44 | 10.3 | 2.7 | 5.1 | 186.0 | 212 | 105 | 89 | 18 | 56 | 106 | 1 | 0 | 0 | 0 | 17 | 6 | 0 | 4.12 |
| CL | Saito, T.Saito, Takashi † >> | 37 | 2007 | R | 100 | 60 | 0 | 5 | 3 | 1.75 | .233 | 0.91 | 5.2 | 3.0 | 10.1 | 67.0 | 39 | 13 | 13 | 4 | 22 | 75 | 0 | 35 | 2 | 0 | 0 | 0 | 0 | 2.52 |
| RP | Perez, R.Perez, Rafael >> | 25 | 2007 | L | 90 | 99 | 0 | 2 | 0 | 2.62 | .285 | 1.20 | 7.8 | 2.9 | 9.2 | 86.0 | 75 | 25 | 25 | 8 | 28 | 88 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 3.14 |
| RP | Delcarmen, M.Delcarmen, Manny >> | 25 | 2007 | R | 86 | 95 | 0 | 3 | 2 | 4.12 | .331 | 1.43 | 8.1 | 4.9 | 6.7 | 98.1 | 88 | 50 | 45 | 11 | 53 | 73 | 0 | 2 | 3 | 0 | 0 | 5 | 0 | 4.74 |
| RP | Herges, M.Herges, Matt >> | 37 | 2007 | R | 80 | 56 | 0 | 4 | 2 | 2.57 | .289 | 1.21 | 6.1 | 4.7 | 6.4 | 63.0 | 43 | 18 | 18 | 3 | 33 | 45 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 3.81 |
| RP | Cordero, F.Cordero, Francisco >> | 32 | 2007 | R | 77 | 42 | 0 | 5 | 0 | 2.96 | .315 | 1.38 | 8.6 | 4.0 | 10.2 | 45.2 | 43 | 17 | 15 | 6 | 20 | 51 | 0 | 1 | 0 | 0 | 0 | 0 | 3 | 3.80 |
| RP | Broxton, J.Broxton, Jonathan >> | 23 | 2007 | R | 66 | 37 | 0 | 1 | 1 | 3.10 | .330 | 1.45 | 8.6 | 4.7 | 8.6 | 40.2 | 38 | 16 | 14 | 2 | 21 | 38 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 3.40 |
| RP | Shields, S.Shields, Scot >> | 32 | 2007 | R | 55 | 38 | 0 | 0 | 3 | 3.31 | .355 | 1.59 | 8.6 | 5.7 | 9.4 | 49.0 | 47 | 18 | 18 | 3 | 31 | 51 | 0 | 2 | 0 | 0 | 0 | 3 | 1 | 3.80 |
| SP | Blanton, J.Blanton, Joe >> | 27 | 2007 | R | 59 | 33 | 32 | 12 | 14 | 5.15 | .338 | 1.48 | 10.8 | 2.6 | 5.6 | 185.1 | 221 | 113 | 106 | 18 | 53 | 116 | 1 | 0 | 0 | 0 | 15 | 10 | 1 | 4.03 |