| SP | Hernandez, O.Hernandez, Orlando >> | 42 | 2007 | R | 95 | 34 | 34 | 8 | 10 | 3.37 | .300 | 1.26 | 7.5 | 3.9 | 6.7 | 192.1 | 159 | 74 | 72 | 17 | 83 | 142 | 0 | 0 | 0 | 0 | 17 | 5 | 2 | 4.05 |
| SP | Bergmann, J.Bergmann, Jay >> | 26 | 2007 | R | 80 | 33 | 33 | 10 | 9 | 3.72 | .293 | 1.23 | 8.3 | 2.9 | 5.6 | 183.2 | 168 | 76 | 76 | 17 | 58 | 114 | 0 | 0 | 0 | 0 | 15 | 2 | 3 | 3.95 |
| SP | Buehrle, M.Buehrle, Mark >> | 28 | 2007 | L | 54 | 32 | 32 | 8 | 10 | 4.54 | .327 | 1.44 | 10.0 | 2.9 | 5.8 | 206.0 | 230 | 107 | 104 | 23 | 67 | 132 | 0 | 0 | 0 | 0 | 16 | 3 | 1 | 4.19 |
| SP | Francis, J.Francis, Jeff # >> | 26 | 2007 | L | 36 | 31 | 31 | 8 | 15 | 4.51 | .316 | 1.36 | 9.8 | 2.5 | 5.9 | 199.2 | 217 | 106 | 100 | 25 | 55 | 130 | 2 | 0 | 0 | 0 | 18 | 5 | 3 | 4.23 |
| RP | Percival, T.Percival, Troy >> | 38 | 2007 | R | 97 | 82 | 0 | 3 | 7 | 3.45 | .277 | 1.12 | 7.1 | 3.0 | 7.1 | 107.0 | 84 | 43 | 41 | 11 | 36 | 84 | 0 | 1 | 3 | 0 | 0 | 3 | 9 | 3.86 |
| RP | Isringhausen, J.Isringhausen, Jason >> | 35 | 2007 | R | 83 | 87 | 0 | 4 | 3 | 3.69 | .312 | 1.33 | 7.3 | 4.7 | 5.7 | 100.0 | 81 | 42 | 41 | 3 | 52 | 63 | 0 | 7 | 1 | 0 | 0 | 3 | 4 | 3.78 |
| RP | Brocail, D.Brocail, Doug >> | 40 | 2007 | R | 48 | 73 | 0 | 6 | 7 | 4.31 | .327 | 1.41 | 9.4 | 3.4 | 6.4 | 87.2 | 91 | 56 | 42 | 13 | 33 | 62 | 0 | 13 | 5 | 0 | 0 | 4 | 0 | 4.79 |
| RP | Oliver, D.Oliver, Darren >> | 37 | 2007 | L | 39 | 50 | 0 | 5 | 4 | 3.54 | .285 | 1.07 | 6.1 | 3.5 | 6.9 | 56.0 | 38 | 25 | 22 | 6 | 22 | 43 | 0 | 3 | 3 | 0 | 0 | 7 | 0 | 4.41 |
| SP | Sonnanstine, A.Sonnanstine, Andy >> | 24 | 2007 | R | 25 | 5 | 0 | 1 | 0 | 15.43 | .500 | 3.00 | 27.0 | 4.5 | 6.8 | 4.2 | 12 | 8 | 8 | 0 | 2 | 3 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 3.00 |
| SP | Washburn, J.Washburn, Jarrod >> | 33 | 2007 | L | 30 | 31 | 0 | 8 | 4 | 5.18 | .354 | 1.58 | 10.5 | 3.9 | 5.4 | 48.2 | 56 | 28 | 28 | 4 | 21 | 29 | 0 | 4 | 2 | 0 | 0 | 3 | 0 | 4.38 |