| SP | Johnson, W.Johnson, Walter † >> | 26 | 1913 | R | 95 | 37 | 37 | 25 | 8 | 2.81 | .257 | 1.01 | 7.0 | 2.1 | 4.6 | 291.2 | 227 | 100 | 91 | 22 | 68 | 149 | 11 | 0 | 0 | 4 | 27 | 8 | 2 | 3.74 |
| SP | Leonard, D.Leonard, Dutch >> | 22 | 1914 | L | 91 | 36 | 36 | 21 | 7 | 3.37 | .271 | 1.09 | 6.6 | 3.2 | 5.5 | 227.1 | 167 | 88 | 85 | 14 | 81 | 139 | 2 | 0 | 0 | 2 | 19 | 6 | 3 | 3.73 |
| SP | Ryan, N.Ryan, Nolan † $$ >> | 44 | 1991 | R | 73 | 36 | 36 | 21 | 8 | 3.93 | .302 | 1.27 | 6.4 | 5.0 | 8.7 | 222.1 | 159 | 104 | 97 | 20 | 123 | 215 | 2 | 0 | 0 | 0 | 21 | 7 | 11 | 3.99 |
| SP | Kluber, C.Kluber, Corey # >> | 31 | 2017 | R | 90 | 33 | 33 | 15 | 13 | 4.13 | .286 | 1.18 | 7.7 | 2.9 | 9.0 | 224.2 | 192 | 109 | 103 | 33 | 73 | 223 | 4 | 0 | 0 | 1 | 16 | 5 | 4 | 3.97 |
| SP | Hunter, C.Hunter, Catfish >> | 26 | 1972 | R | 81 | 36 | 34 | 12 | 13 | 4.34 | .308 | 1.33 | 8.6 | 3.4 | 4.6 | 238.2 | 228 | 123 | 115 | 31 | 89 | 121 | 2 | 0 | 0 | 0 | 17 | 2 | 7 | 4.82 |
| CL | Wagner, B.Wagner, Billy † >> | 28 | 1999 | L | 95 | 75 | 0 | 4 | 7 | 2.19 | .254 | 1.00 | 5.4 | 3.6 | 10.1 | 82.1 | 49 | 24 | 20 | 2 | 33 | 92 | 0 | 56 | 5 | 0 | 0 | 2 | 0 | 2.35 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 85 | 0 | 8 | 3 | 2.51 | .259 | 1.01 | 6.2 | 2.9 | 9.9 | 100.1 | 69 | 29 | 28 | 10 | 32 | 110 | 0 | 4 | 3 | 0 | 0 | 4 | 0 | 3.18 |
| RP | Rivera, M.Rivera, Mariano $ >> | 39 | 2008 | R | 86 | 52 | 0 | 2 | 1 | 1.54 | .240 | 0.91 | 6.9 | 1.4 | 8.5 | 52.2 | 40 | 9 | 9 | 2 | 8 | 49 | 0 | 2 | 1 | 0 | 0 | 2 | 0 | 2.19 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 83 | 12 | 0 | 0 | 1 | 4.76 | .370 | 1.76 | 9.0 | 7.4 | 12.3 | 11.1 | 11 | 8 | 6 | 3 | 9 | 15 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6.27 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 71 | 3 | 0 | 0 | 0 | 15.43 | .417 | 2.14 | 22.5 | 0.0 | 13.5 | 2.1 | 5 | 4 | 4 | 1 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6.50 |
| SP | Gooden, D.Gooden, Dwight >> | 21 | 1985 | R | 68 | 19 | 0 | 5 | 0 | 4.93 | .322 | 1.36 | 9.9 | 2.4 | 4.6 | 87.2 | 96 | 53 | 48 | 11 | 23 | 44 | 0 | 0 | 0 | 0 | 0 | 6 | 2 | 4.63 |