| SP | deGrom, J.deGrom, Jacob $ >> | 33 | 2021 | R | 100 | 9 | 9 | 4 | 3 | 3.29 | .257 | 0.99 | 6.8 | 2.2 | 8.4 | 65.2 | 49 | 24 | 24 | 8 | 16 | 61 | 1 | 0 | 0 | 0 | 6 | 3 | 0 | 3.60 |
| SP | Alexander, P.Alexander, Pete >> | 28 | 1915 | R | 88 | 9 | 9 | 5 | 2 | 4.69 | .326 | 1.42 | 9.0 | 3.9 | 4.9 | 63.1 | 63 | 33 | 33 | 6 | 27 | 34 | 1 | 0 | 0 | 0 | 4 | 2 | 2 | 4.54 |
| SP | Marichal, J.Marichal, Juan >> | 29 | 1966 | R | 77 | 9 | 9 | 3 | 5 | 4.88 | .292 | 1.19 | 9.0 | 1.8 | 5.0 | 66.1 | 66 | 36 | 36 | 12 | 13 | 37 | 4 | 0 | 0 | 0 | 4 | 3 | 1 | 4.97 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 79 | 10 | 9 | 2 | 5 | 4.79 | .343 | 1.55 | 9.6 | 4.4 | 4.9 | 62.0 | 66 | 33 | 33 | 7 | 30 | 34 | 3 | 0 | 0 | 0 | 3 | 1 | 0 | 4.87 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 92 | 9 | 9 | 4 | 4 | 4.90 | .325 | 1.45 | 10.3 | 2.8 | 7.9 | 64.1 | 73 | 37 | 35 | 11 | 20 | 56 | 1 | 0 | 0 | 1 | 3 | 0 | 1 | 4.42 |
| CL | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 16 | 0 | 0 | 0 | 1.20 | .211 | 0.80 | 3.6 | 3.6 | 8.4 | 15.0 | 6 | 2 | 2 | 1 | 6 | 14 | 0 | 13 | 0 | 0 | 0 | 0 | 2 | 3.20 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 16 | 0 | 0 | 1 | 1.59 | .244 | 0.97 | 6.5 | 2.5 | 9.0 | 11.1 | 8 | 2 | 2 | 1 | 3 | 11 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.00 |
| RP | Gossage, R.Gossage, Rich >> | 30 | 1981 | R | 89 | 7 | 0 | 1 | 0 | 5.79 | .364 | 1.50 | 6.8 | 9.0 | 9.0 | 4.2 | 3 | 3 | 3 | 0 | 4 | 4 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.75 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 84 | 6 | 0 | 0 | 0 | 1.29 | .160 | 0.57 | 5.1 | 0.0 | 7.7 | 7.0 | 4 | 1 | 1 | 1 | 0 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.14 |