| SP | Coveleski, S.Coveleski, Stan >> | 28 | 1917 | R | 62 | 32 | 32 | 8 | 10 | 5.31 | .344 | 1.56 | 9.3 | 4.8 | 4.5 | 178.0 | 183 | 109 | 105 | 17 | 94 | 89 | 0 | 0 | 0 | 0 | 18 | 3 | 2 | 4.88 |
| SP | Drysdale, D.Drysdale, Don >> | 28 | 1964 | R | 59 | 31 | 31 | 8 | 16 | 6.52 | .365 | 1.68 | 11.6 | 3.6 | 5.2 | 196.0 | 252 | 157 | 142 | 20 | 78 | 114 | 4 | 0 | 0 | 1 | 10 | 8 | 4 | 4.48 |
| RP | Hader, J.Hader, Josh † >> | 24 | 2018 | L | 94 | 86 | 0 | 8 | 7 | 3.12 | .291 | 1.22 | 7.2 | 3.8 | 9.8 | 135.2 | 108 | 54 | 47 | 18 | 57 | 147 | 0 | 4 | 7 | 0 | 0 | 2 | 0 | 3.87 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 67 | 76 | 0 | 7 | 7 | 4.44 | .325 | 1.37 | 8.3 | 4.1 | 5.9 | 95.1 | 88 | 49 | 47 | 13 | 43 | 62 | 0 | 9 | 3 | 0 | 0 | 7 | 1 | 5.05 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 57 | 44 | 0 | 6 | 6 | 5.53 | .351 | 1.61 | 8.0 | 6.6 | 6.1 | 86.1 | 76 | 53 | 53 | 9 | 63 | 58 | 0 | 3 | 5 | 0 | 0 | 1 | 3 | 5.24 |
| RP | Eichhorn, M.Eichhorn, Mark >> | 26 | 1986 | R | 48 | 37 | 0 | 3 | 2 | 4.17 | .324 | 1.44 | 9.3 | 3.7 | 7.6 | 58.1 | 60 | 27 | 27 | 5 | 24 | 49 | 0 | 3 | 2 | 0 | 0 | 0 | 2 | 3.67 |
| RP | Rodriguez, F.Rodriguez, Felix >> | 29 | 2001 | R | 42 | 31 | 0 | 0 | 1 | 3.06 | .259 | 1.05 | 6.9 | 2.6 | 7.5 | 35.1 | 27 | 13 | 12 | 2 | 10 | 29 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 2.94 |
| SP | McGinnity, J.McGinnity, Joe >> | 33 | 1904 | R | 50 | 10 | 0 | 1 | 0 | 5.84 | .422 | 2.19 | 16.5 | 3.8 | 4.5 | 12.1 | 22 | 8 | 8 | 2 | 5 | 6 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 5.42 |