| SP | Verlander, J.Verlander, Justin >> | 36 | 2019 | R | 99 | 25 | 25 | 10 | 12 | 4.46 | .312 | 1.33 | 8.5 | 3.6 | 8.0 | 169.2 | 159 | 86 | 84 | 27 | 67 | 150 | 4 | 0 | 0 | 0 | 14 | 5 | 1 | 4.58 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 25 | 25 | 9 | 12 | 5.04 | .309 | 1.33 | 8.8 | 3.3 | 8.3 | 151.2 | 147 | 86 | 85 | 28 | 55 | 140 | 0 | 0 | 0 | 0 | 12 | 1 | 5 | 4.67 |
| SP | Bender, C.Bender, Chief # >> | 26 | 1910 | R | 72 | 24 | 24 | 9 | 11 | 5.07 | .316 | 1.38 | 9.6 | 2.8 | 4.8 | 181.0 | 194 | 105 | 102 | 31 | 56 | 97 | 7 | 0 | 0 | 0 | 10 | 1 | 3 | 5.10 |
| SP | Coveleski, S.Coveleski, Stan >> | 28 | 1917 | R | 62 | 23 | 23 | 10 | 10 | 4.05 | .312 | 1.32 | 7.8 | 4.1 | 4.5 | 153.1 | 133 | 74 | 69 | 19 | 70 | 76 | 1 | 0 | 0 | 1 | 14 | 6 | 2 | 5.11 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 73 | 42 | 0 | 3 | 1 | 3.00 | .273 | 1.13 | 5.3 | 4.9 | 11.6 | 48.0 | 28 | 16 | 16 | 5 | 26 | 62 | 0 | 3 | 1 | 0 | 0 | 0 | 2 | 3.40 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 57 | 24 | 0 | 1 | 0 | 3.05 | .269 | 1.08 | 5.3 | 4.5 | 5.1 | 44.1 | 26 | 16 | 15 | 3 | 22 | 25 | 0 | 1 | 1 | 0 | 0 | 1 | 2 | 4.32 |
| SP | Camnitz, H.Camnitz, Howie >> | 28 | 1909 | R | 58 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 58 | 6 | 0 | 0 | 2 | 5.87 | .258 | 1.04 | 9.0 | 1.3 | 3.9 | 7.2 | 7 | 5 | 5 | 3 | 1 | 3 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 8.14 |