| SP | Martinez, P.Martinez, Pedro † >> | 29 | 2000 | R | 100 | 25 | 25 | 15 | 5 | 3.63 | .269 | 1.09 | 7.3 | 2.5 | 9.0 | 161.0 | 131 | 73 | 65 | 21 | 45 | 161 | 2 | 0 | 0 | 1 | 15 | 2 | 1 | 3.57 |
| SP | Johnson, R.Johnson, Randy † # >> | 41 | 2004 | L | 84 | 24 | 24 | 12 | 8 | 3.71 | .289 | 1.21 | 8.9 | 2.1 | 8.8 | 162.1 | 160 | 73 | 67 | 19 | 37 | 158 | 5 | 0 | 0 | 1 | 16 | 1 | 3 | 3.28 |
| SP | Clemens, R.Clemens, Roger >> | 24 | 1986 | R | 69 | 27 | 23 | 8 | 9 | 6.40 | .377 | 1.78 | 11.5 | 4.6 | 6.0 | 128.0 | 163 | 102 | 91 | 23 | 65 | 85 | 1 | 0 | 0 | 0 | 7 | 4 | 5 | 5.63 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 65 | 0 | 5 | 2 | 4.74 | .313 | 1.37 | 8.3 | 4.0 | 8.6 | 76.0 | 70 | 43 | 40 | 11 | 34 | 73 | 0 | 4 | 4 | 0 | 0 | 0 | 0 | 4.30 |
| RP | Gossage, R.Gossage, Rich >> | 30 | 1981 | R | 89 | 70 | 0 | 5 | 2 | 4.70 | .295 | 1.25 | 8.3 | 3.0 | 7.5 | 84.1 | 77 | 48 | 44 | 13 | 28 | 70 | 0 | 6 | 1 | 0 | 0 | 1 | 3 | 4.38 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 84 | 55 | 0 | 2 | 4 | 4.90 | .316 | 1.34 | 9.2 | 3.0 | 8.4 | 60.2 | 61 | 34 | 33 | 6 | 20 | 56 | 0 | 1 | 2 | 0 | 0 | 3 | 0 | 3.58 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 76 | 38 | 0 | 1 | 1 | 6.66 | .374 | 1.77 | 10.9 | 5.1 | 8.1 | 51.1 | 62 | 40 | 38 | 13 | 29 | 46 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 6.27 |