| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 33 | 33 | 14 | 7 | 3.50 | .291 | 1.20 | 7.7 | 3.1 | 10.3 | 206.0 | 176 | 86 | 80 | 23 | 71 | 235 | 1 | 0 | 0 | 1 | 21 | 7 | 0 | 3.31 |
| SP | Gibson, B.Gibson, Bob # >> | 33 | 1968 | R | 92 | 32 | 32 | 9 | 16 | 5.33 | .330 | 1.45 | 10.0 | 3.0 | 5.7 | 207.2 | 231 | 130 | 123 | 17 | 70 | 130 | 10 | 0 | 0 | 1 | 13 | 6 | 3 | 3.91 |
| SP | Kluber, C.Kluber, Corey # >> | 31 | 2017 | R | 89 | 31 | 31 | 11 | 11 | 5.20 | .319 | 1.35 | 8.8 | 3.4 | 8.6 | 202.1 | 198 | 127 | 117 | 25 | 76 | 192 | 2 | 0 | 0 | 0 | 12 | 10 | 3 | 3.99 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 76 | 30 | 30 | 16 | 4 | 5.96 | .361 | 1.67 | 9.7 | 5.4 | 7.4 | 164.2 | 177 | 116 | 109 | 20 | 98 | 134 | 0 | 0 | 0 | 0 | 11 | 4 | 2 | 4.82 |
| SU | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 62 | 0 | 2 | 6 | 3.32 | .310 | 1.32 | 6.0 | 5.8 | 7.4 | 57.0 | 38 | 24 | 21 | 3 | 37 | 47 | 0 | 2 | 3 | 0 | 0 | 2 | 1 | 4.09 |
| CL | Chapman, A.Chapman, Aroldis >> | 26 | 2014 | L | 93 | 58 | 0 | 3 | 10 | 3.75 | .329 | 1.44 | 6.9 | 6.2 | 10.6 | 57.2 | 44 | 26 | 24 | 3 | 39 | 67 | 0 | 35 | 7 | 0 | 0 | 2 | 0 | 3.49 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 77 | 61 | 0 | 2 | 1 | 3.13 | .310 | 1.35 | 7.2 | 4.9 | 7.0 | 46.0 | 37 | 25 | 16 | 4 | 25 | 36 | 0 | 2 | 2 | 0 | 0 | 0 | 5 | 4.20 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 76 | 0 | 5 | 2 | 2.17 | .240 | 0.95 | 6.4 | 2.2 | 7.8 | 58.0 | 41 | 16 | 14 | 3 | 14 | 50 | 0 | 2 | 4 | 0 | 0 | 0 | 0 | 2.67 |
| SP | Krause, H.Krause, Harry >> | 21 | 1909 | L | 71 | 25 | 0 | 4 | 2 | 4.90 | .311 | 1.34 | 8.8 | 3.4 | 3.8 | 75.1 | 73 | 43 | 41 | 6 | 28 | 32 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 4.35 |