| SP | McNally, D.McNally, Dave † >> | 26 | 1968 | L | 96 | 35 | 35 | 18 | 13 | 3.12 | .275 | 1.11 | 7.3 | 2.8 | 5.1 | 274.1 | 221 | 104 | 95 | 30 | 84 | 154 | 15 | 0 | 0 | 3 | 24 | 7 | 3 | 4.30 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 34 | 34 | 7 | 15 | 4.28 | .304 | 1.30 | 8.4 | 3.3 | 7.8 | 210.1 | 196 | 107 | 100 | 26 | 77 | 181 | 1 | 0 | 0 | 1 | 19 | 3 | 4 | 4.03 |
| SP | Horlen, J.Horlen, Joe # >> | 27 | 1964 | R | 78 | 33 | 33 | 13 | 10 | 4.87 | .324 | 1.42 | 9.7 | 3.1 | 5.1 | 212.1 | 228 | 121 | 115 | 26 | 74 | 121 | 2 | 0 | 0 | 0 | 18 | 4 | 5 | 4.56 |
| SP | Chesbro, J.Chesbro, Jack # >> | 30 | 1904 | R | 65 | 33 | 33 | 15 | 15 | 5.44 | .325 | 1.43 | 10.2 | 2.7 | 4.4 | 223.1 | 252 | 142 | 135 | 35 | 67 | 110 | 12 | 0 | 0 | 2 | 12 | 3 | 5 | 5.00 |
| SP | Coveleski, S.Coveleski, Stan >> | 28 | 1917 | R | 62 | 31 | 31 | 13 | 10 | 4.94 | .340 | 1.53 | 8.8 | 4.9 | 4.7 | 175.0 | 171 | 103 | 96 | 20 | 96 | 91 | 0 | 0 | 0 | 0 | 12 | 4 | 1 | 5.16 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 79 | 0 | 7 | 7 | 3.90 | .281 | 1.15 | 6.3 | 4.1 | 8.0 | 115.1 | 81 | 55 | 50 | 8 | 52 | 102 | 0 | 7 | 4 | 0 | 0 | 2 | 1 | 3.54 |
| RP | Wilhelm, H.Wilhelm, Hoyt >> | 43 | 1965 | R | 69 | 74 | 0 | 4 | 4 | 4.32 | .319 | 1.39 | 9.2 | 3.3 | 5.4 | 123.0 | 126 | 68 | 59 | 20 | 45 | 74 | 0 | 18 | 3 | 0 | 0 | 2 | 6 | 5.06 |
| RP | Drabowsky, M.Drabowsky, Moe >> | 31 | 1966 | R | 54 | 37 | 0 | 1 | 4 | 4.55 | .349 | 1.57 | 9.5 | 4.7 | 8.5 | 55.1 | 58 | 30 | 28 | 7 | 29 | 52 | 0 | 2 | 2 | 0 | 0 | 2 | 0 | 4.45 |
| SP | Halladay, R.Halladay, Roy >> | 28 | 2005 | R | 48 | 2 | 0 | 0 | 1 | 2.45 | .421 | 2.18 | 18.0 | 6.0 | 9.0 | 3.2 | 6 | 2 | 1 | 0 | 2 | 3 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.00 |
| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 55 | 18 | 0 | 4 | 0 | 3.45 | .344 | 1.57 | 12.2 | 2.3 | 6.1 | 28.2 | 38 | 13 | 11 | 2 | 7 | 19 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 3.32 |