| SP | Leonard, D.Leonard, Dutch >> | 22 | 1914 | L | 91 | 32 | 32 | 17 | 8 | 3.74 | .290 | 1.22 | 8.1 | 2.9 | 5.4 | 202.1 | 182 | 86 | 84 | 14 | 64 | 121 | 3 | 0 | 0 | 2 | 20 | 2 | 0 | 3.68 |
| SP | Johnson, R.Johnson, Randy # >> | 41 | 2004 | L | 84 | 31 | 31 | 14 | 7 | 4.18 | .308 | 1.31 | 9.3 | 2.5 | 7.3 | 180.2 | 186 | 86 | 84 | 23 | 50 | 146 | 0 | 0 | 0 | 0 | 18 | 5 | 4 | 3.96 |
| SP | Guidry, R.Guidry, Ron # >> | 28 | 1978 | L | 77 | 31 | 31 | 13 | 12 | 4.01 | .283 | 1.17 | 7.6 | 2.9 | 5.9 | 215.1 | 182 | 98 | 96 | 16 | 70 | 140 | 12 | 0 | 0 | 5 | 15 | 3 | 4 | 3.68 |
| SP | McDowell, S.McDowell, Sam † >> | 26 | 1968 | L | 45 | 30 | 29 | 14 | 9 | 3.62 | .303 | 1.27 | 6.8 | 4.6 | 7.7 | 186.2 | 141 | 82 | 75 | 21 | 96 | 160 | 2 | 0 | 0 | 0 | 16 | 6 | 7 | 4.39 |
| RP | Gagne, E.Gagne, Eric † >> | 27 | 2003 | R | 98 | 77 | 0 | 8 | 3 | 2.12 | .243 | 0.95 | 5.6 | 3.0 | 8.3 | 106.0 | 66 | 28 | 25 | 13 | 35 | 98 | 0 | 10 | 5 | 0 | 0 | 1 | 3 | 3.76 |
| RP | Wagner, B.Wagner, Billy >> | 28 | 1999 | L | 95 | 62 | 0 | 2 | 1 | 2.50 | .262 | 1.06 | 6.7 | 3.0 | 7.7 | 82.2 | 61 | 23 | 23 | 8 | 27 | 70 | 0 | 11 | 4 | 0 | 0 | 0 | 2 | 3.55 |
| RP | Miller, A.Miller, Andrew >> | 29 | 2014 | L | 88 | 31 | 0 | 1 | 0 | 2.55 | .248 | 0.93 | 6.4 | 2.1 | 7.5 | 35.1 | 25 | 10 | 10 | 5 | 8 | 29 | 0 | 4 | 0 | 0 | 0 | 2 | 1 | 4.06 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 10 | 0 | 2 | 1 | 1.69 | .256 | 1.03 | 3.6 | 6.3 | 10.8 | 10.2 | 4 | 2 | 2 | 2 | 7 | 12 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 5.30 |
| RP | Eichhorn, M.Eichhorn, Mark # >> | 26 | 1986 | R | 48 | 31 | 0 | 3 | 1 | 5.63 | .341 | 1.51 | 9.5 | 4.1 | 7.5 | 70.1 | 74 | 46 | 44 | 13 | 32 | 58 | 0 | 2 | 0 | 0 | 0 | 3 | 1 | 5.26 |