| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 96 | 18 | 18 | 7 | 4 | 3.02 | .262 | 1.03 | 6.9 | 2.4 | 8.9 | 134.0 | 103 | 47 | 45 | 15 | 35 | 132 | 2 | 0 | 0 | 0 | 14 | 5 | 5 | 3.38 |
| SP | Reulbach, E.Reulbach, Ed † >> | 24 | 1906 | R | 60 | 17 | 17 | 10 | 2 | 3.05 | .339 | 1.53 | 8.7 | 5.1 | 4.5 | 112.0 | 108 | 38 | 38 | 4 | 63 | 56 | 1 | 0 | 0 | 0 | 13 | 1 | 0 | 4.18 |
| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 56 | 17 | 17 | 9 | 6 | 3.87 | .331 | 1.48 | 10.4 | 2.9 | 6.0 | 102.1 | 118 | 47 | 44 | 4 | 33 | 68 | 0 | 0 | 0 | 0 | 9 | 1 | 1 | 3.18 |
| SP | Brown, M.Brown, Mordecai # >> | 28 | 1904 | R | 57 | 16 | 16 | 6 | 8 | 4.36 | .306 | 1.33 | 9.3 | 2.7 | 4.8 | 117.2 | 121 | 60 | 57 | 9 | 35 | 62 | 7 | 0 | 0 | 1 | 6 | 0 | 2 | 3.84 |
| SP | Pfiester, J.Pfiester, Jack >> | 29 | 1907 | L | 53 | 16 | 16 | 5 | 5 | 3.86 | .315 | 1.38 | 9.2 | 3.3 | 5.5 | 105.0 | 107 | 49 | 45 | 9 | 38 | 64 | 1 | 0 | 0 | 1 | 9 | 0 | 0 | 3.98 |
| RP | Edwards, C.Edwards, Carl >> | 24 | 2016 | R | 98 | 40 | 0 | 3 | 2 | 2.23 | .306 | 1.32 | 7.9 | 4.1 | 9.8 | 48.1 | 42 | 14 | 12 | 4 | 22 | 52 | 0 | 2 | 3 | 0 | 0 | 0 | 5 | 3.29 |
| RP | Tepera, R.Tepera, Ryan >> | 33 | 2021 | R | 93 | 33 | 0 | 2 | 3 | 2.55 | .270 | 1.06 | 6.2 | 3.4 | 8.8 | 42.1 | 29 | 12 | 12 | 2 | 16 | 41 | 0 | 4 | 1 | 0 | 0 | 2 | 0 | 2.95 |
| RP | Miller, T.Miller, Tyson >> | 28 | 2024 | R | 77 | 17 | 0 | 0 | 2 | 4.40 | .358 | 1.67 | 12.2 | 3.2 | 7.7 | 14.1 | 19 | 7 | 7 | 3 | 5 | 12 | 0 | 5 | 1 | 0 | 0 | 0 | 0 | 5.14 |
| RP | Wesneski, H.Wesneski, Hayden >> | 24 | 2022 | R | 51 | 15 | 0 | 1 | 1 | 4.15 | .371 | 1.69 | 8.3 | 6.9 | 6.9 | 13.0 | 12 | 6 | 6 | 2 | 10 | 10 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 6.00 |
| RP | Rondon, H.Rondon, Hector >> | 28 | 2016 | R | 48 | 16 | 0 | 0 | 0 | 3.63 | .257 | 0.98 | 6.9 | 2.1 | 10.6 | 17.1 | 13 | 7 | 7 | 3 | 4 | 20 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 3.82 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 83 | 7 | 0 | 2 | 1 | 4.15 | .350 | 1.62 | 10.1 | 4.8 | 7.4 | 17.1 | 19 | 8 | 8 | 4 | 9 | 14 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6.00 |