| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 92 | 16 | 16 | 6 | 5 | 3.75 | .300 | 1.27 | 8.8 | 2.6 | 9.6 | 110.1 | 108 | 50 | 46 | 12 | 32 | 117 | 2 | 0 | 0 | 1 | 10 | 2 | 0 | 3.22 |
| SP | Brown, M.Brown, Mordecai >> | 32 | 1908 | R | 81 | 17 | 17 | 9 | 6 | 3.55 | .287 | 1.19 | 8.2 | 2.5 | 4.8 | 124.1 | 113 | 52 | 49 | 12 | 35 | 66 | 5 | 0 | 0 | 1 | 9 | 2 | 3 | 4.09 |
| SP | Reulbach, E.Reulbach, Ed >> | 24 | 1906 | R | 55 | 17 | 17 | 8 | 4 | 3.30 | .286 | 1.19 | 5.9 | 4.9 | 5.6 | 109.0 | 71 | 44 | 40 | 4 | 59 | 68 | 2 | 0 | 0 | 1 | 10 | 1 | 1 | 3.88 |
| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 50 | 16 | 16 | 6 | 3 | 3.57 | .302 | 1.28 | 9.2 | 2.4 | 5.7 | 103.1 | 105 | 43 | 41 | 8 | 27 | 65 | 0 | 0 | 0 | 0 | 10 | 2 | 1 | 3.59 |
| SP | Pfiester, J.Pfiester, Jack >> | 29 | 1907 | L | 45 | 16 | 16 | 5 | 7 | 5.94 | .338 | 1.51 | 10.4 | 3.2 | 4.2 | 89.1 | 103 | 60 | 59 | 14 | 32 | 42 | 1 | 0 | 0 | 0 | 8 | 2 | 0 | 5.25 |
| RP | Edwards, C.Edwards, Carl † >> | 24 | 2016 | R | 98 | 44 | 0 | 6 | 1 | 2.79 | .296 | 1.24 | 5.9 | 5.3 | 9.0 | 58.0 | 38 | 18 | 18 | 4 | 34 | 58 | 0 | 6 | 3 | 0 | 0 | 1 | 4 | 3.71 |
| RP | Tepera, R.Tepera, Ryan † >> | 33 | 2021 | R | 93 | 44 | 0 | 7 | 2 | 2.19 | .252 | 1.01 | 5.3 | 3.9 | 8.8 | 53.1 | 31 | 14 | 13 | 4 | 23 | 52 | 0 | 7 | 0 | 0 | 0 | 0 | 2 | 3.32 |
| RP | Hodge, P.Hodge, Porter >> | 23 | 2024 | R | 85 | 25 | 0 | 3 | 0 | 1.63 | .284 | 1.19 | 6.0 | 5.0 | 8.0 | 27.2 | 18 | 5 | 5 | 1 | 15 | 24 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 3.37 |
| RP | Miller, T.Miller, Tyson >> | 28 | 2024 | R | 72 | 10 | 0 | 1 | 0 | 1.74 | .326 | 1.45 | 10.8 | 2.7 | 4.5 | 10.1 | 12 | 4 | 2 | 1 | 3 | 5 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.20 |
| RP | Rondon, H.Rondon, Hector >> | 28 | 2016 | R | 41 | 12 | 0 | 0 | 0 | 7.30 | .383 | 1.78 | 10.5 | 6.0 | 9.8 | 12.1 | 14 | 10 | 10 | 2 | 8 | 13 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 5.25 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 83 | 14 | 1 | 2 | 0 | 2.36 | .295 | 1.22 | 6.4 | 4.8 | 9.8 | 34.1 | 24 | 12 | 9 | 2 | 18 | 37 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 3.26 |