| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 28 | 28 | 9 | 16 | 5.01 | .321 | 1.41 | 8.4 | 4.4 | 9.2 | 169.0 | 157 | 95 | 94 | 23 | 82 | 172 | 1 | 0 | 0 | 0 | 13 | 1 | 4 | 4.21 |
| SP | Drysdale, D.Drysdale, Don # >> | 28 | 1964 | R | 58 | 27 | 27 | 13 | 11 | 4.46 | .315 | 1.37 | 9.4 | 2.9 | 4.9 | 204.0 | 213 | 109 | 101 | 25 | 66 | 111 | 11 | 0 | 0 | 0 | 10 | 3 | 4 | 4.52 |
| SP | Schilling, C.Schilling, Curt >> | 36 | 2002 | R | 49 | 26 | 26 | 2 | 18 | 6.51 | .343 | 1.53 | 11.5 | 2.3 | 7.8 | 160.1 | 205 | 133 | 116 | 30 | 41 | 138 | 2 | 0 | 0 | 0 | 8 | 5 | 4 | 4.58 |
| RP | Benoit, J.Benoit, Joaquin † >> | 33 | 2010 | R | 94 | 67 | 0 | 4 | 0 | 3.70 | .322 | 1.39 | 8.3 | 4.3 | 8.3 | 82.2 | 76 | 37 | 34 | 6 | 39 | 76 | 0 | 8 | 0 | 0 | 0 | 3 | 1 | 3.63 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 71 | 54 | 0 | 0 | 2 | 3.82 | .313 | 1.36 | 7.1 | 5.2 | 9.4 | 66.0 | 52 | 31 | 28 | 4 | 38 | 69 | 0 | 3 | 3 | 0 | 0 | 0 | 4 | 3.42 |
| RP | Perkins, G.Perkins, Glen >> | 30 | 2013 | L | 48 | 36 | 0 | 2 | 1 | 5.40 | .354 | 1.62 | 12.6 | 2.1 | 8.1 | 38.1 | 53 | 26 | 23 | 9 | 9 | 34 | 0 | 0 | 2 | 0 | 0 | 1 | 0 | 5.08 |