| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 13 | 13 | 5 | 5 | 4.75 | .321 | 1.40 | 8.9 | 3.9 | 11.6 | 77.2 | 76 | 42 | 41 | 11 | 33 | 99 | 0 | 0 | 0 | 0 | 6 | 1 | 0 | 3.61 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 92 | 13 | 13 | 8 | 3 | 3.94 | .308 | 1.31 | 7.7 | 4.2 | 9.1 | 91.1 | 78 | 43 | 40 | 6 | 42 | 92 | 2 | 0 | 0 | 1 | 8 | 2 | 3 | 3.29 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 83 | 13 | 13 | 4 | 8 | 6.48 | .342 | 1.53 | 10.2 | 3.7 | 7.3 | 76.1 | 86 | 55 | 55 | 13 | 31 | 62 | 2 | 0 | 0 | 0 | 4 | 2 | 2 | 4.89 |
| SP | McLain, D.McLain, Denny # >> | 24 | 1968 | R | 79 | 12 | 12 | 8 | 4 | 3.13 | .263 | 1.06 | 7.7 | 2.0 | 5.5 | 100.2 | 85 | 35 | 35 | 10 | 22 | 61 | 9 | 0 | 0 | 1 | 7 | 1 | 1 | 3.77 |
| RP | Doolittle, S.Doolittle, Sean $ >> | 31 | 2018 | L | 99 | 30 | 0 | 3 | 0 | 1.35 | .205 | 0.75 | 5.0 | 1.8 | 10.8 | 40.0 | 22 | 7 | 6 | 1 | 8 | 48 | 0 | 5 | 0 | 0 | 0 | 1 | 1 | 1.60 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 27 | 0 | 1 | 3 | 6.04 | .367 | 1.66 | 10.4 | 4.7 | 9.7 | 25.1 | 29 | 19 | 17 | 3 | 13 | 27 | 0 | 5 | 2 | 0 | 0 | 2 | 0 | 4.20 |
| RP | Rivera, M.Rivera, Mariano $ >> | 39 | 2008 | R | 85 | 14 | 0 | 2 | 0 | 1.76 | .246 | 0.98 | 7.8 | 1.2 | 9.0 | 15.1 | 13 | 4 | 3 | 0 | 2 | 15 | 0 | 3 | 1 | 0 | 0 | 0 | 0 | 1.40 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 81 | 8 | 0 | 2 | 0 | 3.24 | .242 | 0.96 | 5.6 | 3.4 | 13.5 | 8.1 | 5 | 3 | 3 | 2 | 3 | 12 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.38 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 70 | 4 | 0 | 0 | 0 | 7.94 | .414 | 1.94 | 5.4 | 14.4 | 3.6 | 5.2 | 3 | 5 | 5 | 0 | 8 | 2 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 7.60 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 74 | 8 | 0 | 1 | 0 | 2.68 | .234 | 0.86 | 6.6 | 1.2 | 4.4 | 37.0 | 27 | 11 | 11 | 4 | 5 | 18 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 4.00 |