| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 38 | 38 | 15 | 10 | 3.28 | .267 | 1.09 | 7.5 | 2.3 | 8.6 | 260.1 | 216 | 101 | 95 | 25 | 67 | 248 | 1 | 0 | 0 | 1 | 23 | 2 | 0 | 3.14 |
| SP | Greinke, Z.Greinke, Zack >> | 32 | 2015 | R | 94 | 36 | 36 | 21 | 11 | 2.97 | .267 | 1.06 | 7.5 | 2.0 | 5.6 | 275.2 | 230 | 92 | 91 | 32 | 62 | 172 | 11 | 0 | 0 | 3 | 25 | 9 | 2 | 4.04 |
| SP | Marichal, J.Marichal, Juan † # >> | 29 | 1966 | R | 76 | 32 | 31 | 14 | 9 | 4.14 | .284 | 1.17 | 8.8 | 1.8 | 4.9 | 230.1 | 225 | 112 | 106 | 34 | 45 | 126 | 17 | 0 | 0 | 3 | 13 | 4 | 3 | 4.47 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 86 | 0 | 6 | 7 | 3.63 | .274 | 1.12 | 7.3 | 2.8 | 8.0 | 106.2 | 86 | 44 | 43 | 16 | 33 | 94 | 0 | 13 | 4 | 0 | 0 | 2 | 5 | 4.18 |
| RP | Miller, A.Miller, Andrew † >> | 31 | 2016 | L | 91 | 62 | 0 | 9 | 1 | 1.75 | .206 | 0.77 | 5.2 | 1.8 | 8.1 | 82.1 | 47 | 16 | 16 | 8 | 16 | 74 | 0 | 17 | 1 | 0 | 0 | 1 | 1 | 3.09 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 36 | 0 | 0 | 3 | 3.21 | .280 | 1.14 | 9.0 | 1.3 | 6.9 | 42.0 | 42 | 18 | 15 | 5 | 6 | 32 | 0 | 5 | 3 | 0 | 0 | 1 | 0 | 3.52 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 82 | 19 | 0 | 2 | 3 | 1.35 | .231 | 0.86 | 4.2 | 3.8 | 8.7 | 26.2 | 12 | 5 | 4 | 1 | 11 | 25 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 2.96 |