| SP | Verlander, J.Verlander, Justin >> | 36 | 2019 | R | 99 | 14 | 14 | 6 | 5 | 5.20 | .328 | 1.43 | 9.2 | 3.8 | 7.9 | 91.2 | 93 | 56 | 53 | 14 | 38 | 80 | 1 | 0 | 0 | 1 | 4 | 3 | 2 | 4.59 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 90 | 13 | 13 | 6 | 4 | 4.08 | .330 | 1.41 | 9.2 | 3.5 | 8.2 | 86.0 | 88 | 44 | 39 | 16 | 33 | 78 | 0 | 0 | 0 | 0 | 9 | 6 | 2 | 4.97 |
| SP | Marichal, J.Marichal, Juan >> | 29 | 1966 | R | 77 | 13 | 13 | 7 | 5 | 5.93 | .335 | 1.49 | 10.6 | 2.7 | 6.3 | 82.0 | 97 | 61 | 54 | 25 | 25 | 57 | 0 | 0 | 0 | 0 | 6 | 2 | 1 | 6.56 |
| SP | Hunter, C.Hunter, Catfish >> | 26 | 1972 | R | 81 | 13 | 13 | 3 | 9 | 8.09 | .385 | 1.82 | 11.8 | 4.8 | 5.3 | 72.1 | 94 | 68 | 65 | 11 | 38 | 42 | 1 | 0 | 0 | 0 | 2 | 4 | 1 | 5.57 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 30 | 0 | 0 | 2 | 5.63 | .329 | 1.47 | 7.6 | 5.6 | 11.3 | 32.0 | 27 | 21 | 20 | 2 | 20 | 40 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 3.19 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 74 | 15 | 0 | 0 | 1 | 5.94 | .333 | 1.44 | 10.1 | 3.4 | 10.1 | 16.2 | 18 | 11 | 11 | 4 | 6 | 18 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 5.31 |
| CL | Wagner, B.Wagner, Billy >> | 28 | 1999 | L | 95 | 24 | 0 | 1 | 1 | 4.29 | .284 | 1.19 | 7.3 | 3.4 | 12.0 | 21.0 | 17 | 12 | 10 | 2 | 8 | 28 | 0 | 17 | 4 | 0 | 0 | 0 | 2 | 2.71 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 71 | 13 | 0 | 0 | 0 | 1.98 | .268 | 1.02 | 5.5 | 4.2 | 9.7 | 13.2 | 8 | 3 | 3 | 1 | 6 | 14 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 3.46 |
| SU | Eckersley, D.Eckersley, Dennis $ >> | 36 | 1990 | R | 88 | 21 | 0 | 0 | 2 | 2.37 | .305 | 1.26 | 9.5 | 1.9 | 9.5 | 19.0 | 20 | 9 | 5 | 2 | 4 | 20 | 0 | 1 | 3 | 0 | 0 | 1 | 0 | 3.05 |
| SP | Hendrix, C.Hendrix, Claude >> | 25 | 1914 | R | 70 | 1 | 0 | 0 | 0 | 0.00 | .333 | 1.50 | - | - | - | 0.2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |