| SP | Martinez, P.Martinez, Pedro $ >> | 29 | 2000 | R | 100 | 34 | 34 | 15 | 11 | 4.15 | .320 | 1.40 | 9.4 | 3.2 | 8.8 | 221.1 | 231 | 106 | 102 | 33 | 78 | 216 | 3 | 0 | 0 | 0 | 18 | 3 | 0 | 4.09 |
| SP | Kluber, C.Kluber, Corey # >> | 31 | 2017 | R | 89 | 34 | 34 | 11 | 12 | 4.88 | .303 | 1.30 | 8.9 | 2.8 | 8.9 | 199.0 | 196 | 108 | 108 | 27 | 63 | 197 | 2 | 0 | 0 | 1 | 16 | 1 | 2 | 3.75 |
| SP | Johnson, R.Johnson, Randy # >> | 41 | 2004 | L | 83 | 32 | 32 | 7 | 13 | 5.88 | .347 | 1.55 | 11.4 | 2.6 | 8.1 | 176.0 | 223 | 127 | 115 | 30 | 50 | 158 | 3 | 0 | 0 | 1 | 13 | 7 | 1 | 4.39 |
| SP | Cueto, J.Cueto, Johnny >> | 28 | 2014 | R | 75 | 32 | 32 | 9 | 13 | 5.48 | .335 | 1.50 | 9.5 | 4.0 | 6.1 | 189.0 | 199 | 124 | 115 | 36 | 85 | 128 | 3 | 0 | 0 | 0 | 14 | 2 | 2 | 5.50 |
| SP | Bender, C.Bender, Chief >> | 26 | 1910 | R | 71 | 36 | 30 | 7 | 15 | 6.21 | .348 | 1.58 | 11.0 | 3.2 | 3.8 | 168.0 | 205 | 126 | 116 | 26 | 60 | 70 | 2 | 0 | 1 | 0 | 10 | 4 | 9 | 5.32 |
| CL | Adams, M.Adams, Mike † >> | 31 | 2009 | R | 99 | 84 | 0 | 7 | 10 | 4.86 | .315 | 1.36 | 8.7 | 3.6 | 8.1 | 92.2 | 89 | 57 | 50 | 7 | 37 | 83 | 0 | 32 | 7 | 0 | 0 | 2 | 3 | 3.46 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 92 | 0 | 5 | 4 | 5.29 | .327 | 1.46 | 8.7 | 4.5 | 8.5 | 95.1 | 92 | 56 | 56 | 17 | 47 | 90 | 0 | 2 | 7 | 0 | 0 | 0 | 0 | 4.92 |
| RP | Gossage, R.Gossage, Rich >> | 30 | 1981 | R | 89 | 91 | 0 | 6 | 2 | 3.69 | .301 | 1.28 | 7.3 | 4.3 | 7.8 | 114.2 | 92 | 52 | 47 | 14 | 55 | 99 | 0 | 0 | 1 | 0 | 0 | 1 | 5 | 4.33 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 75 | 0 | 4 | 1 | 5.00 | .304 | 1.26 | 7.9 | 3.4 | 9.9 | 81.0 | 71 | 50 | 45 | 12 | 31 | 89 | 0 | 1 | 1 | 0 | 0 | 4 | 3 | 4.02 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 77 | 90 | 0 | 5 | 4 | 4.42 | .313 | 1.37 | 7.8 | 4.6 | 7.9 | 95.2 | 82 | 47 | 47 | 8 | 49 | 83 | 0 | 2 | 2 | 0 | 0 | 0 | 8 | 3.89 |