| SP | Mathewson, C.Mathewson, Christy $ >> | 29 | 1909 | R | 85 | 14 | 14 | 7 | 4 | 2.91 | .259 | 1.01 | 6.7 | 2.4 | 4.8 | 99.0 | 74 | 32 | 32 | 10 | 26 | 53 | 2 | 0 | 0 | 1 | 9 | 4 | 0 | 4.15 |
| SP | Koufax, S.Koufax, Sandy # >> | 30 | 1965 | L | 97 | 13 | 13 | 6 | 6 | 3.74 | .239 | 0.91 | 6.8 | 1.4 | 8.3 | 89.0 | 67 | 37 | 37 | 13 | 14 | 82 | 4 | 0 | 0 | 1 | 9 | 3 | 3 | 3.63 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 13 | 13 | 6 | 4 | 4.50 | .284 | 1.19 | 9.0 | 1.7 | 4.5 | 80.0 | 80 | 43 | 40 | 13 | 15 | 40 | 2 | 0 | 0 | 1 | 7 | 0 | 1 | 4.68 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 13 | 13 | 9 | 2 | 2.64 | .265 | 1.07 | 6.1 | 3.6 | 7.1 | 105.2 | 71 | 31 | 31 | 13 | 42 | 83 | 6 | 0 | 0 | 2 | 9 | 1 | 0 | 4.26 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 78 | 13 | 13 | 6 | 3 | 3.26 | .285 | 1.19 | 6.1 | 4.5 | 8.0 | 91.0 | 62 | 34 | 33 | 8 | 46 | 81 | 1 | 0 | 0 | 0 | 8 | 1 | 0 | 3.91 |
| RP | Chapman, A.Chapman, Aroldis >> | 26 | 2014 | L | 93 | 32 | 0 | 4 | 0 | 0.69 | .258 | 1.02 | 4.2 | 5.1 | 10.4 | 39.1 | 18 | 3 | 3 | 0 | 22 | 45 | 0 | 4 | 1 | 0 | 0 | 1 | 3 | 2.46 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 75 | 10 | 0 | 1 | 1 | 2.25 | .294 | 1.25 | 5.6 | 5.6 | 13.5 | 8.0 | 5 | 2 | 2 | 2 | 5 | 12 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 5.13 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 68 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 57 | 1 | 0 | 0 | 0 | 0.00 | .400 | 2.00 | 9.0 | 9.0 | 9.0 | 1.0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.00 |