| SP | Mathewson, C.Mathewson, Christy $ >> | 29 | 1909 | R | 85 | 14 | 14 | 7 | 4 | 2.91 | .259 | 1.01 | 6.7 | 2.4 | 4.8 | 99.0 | 74 | 32 | 32 | 10 | 26 | 53 | 2 | 0 | 0 | 1 | 9 | 4 | 0 | 4.15 |
| SP | Koufax, S.Koufax, Sandy # >> | 30 | 1965 | L | 97 | 13 | 13 | 6 | 6 | 3.74 | .239 | 0.91 | 6.8 | 1.4 | 8.3 | 89.0 | 67 | 37 | 37 | 13 | 14 | 82 | 4 | 0 | 0 | 1 | 9 | 3 | 3 | 3.63 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 13 | 13 | 6 | 4 | 4.50 | .284 | 1.19 | 9.0 | 1.7 | 4.5 | 80.0 | 80 | 43 | 40 | 13 | 15 | 40 | 2 | 0 | 0 | 1 | 7 | 0 | 1 | 4.68 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 13 | 13 | 9 | 2 | 2.64 | .265 | 1.07 | 6.1 | 3.6 | 7.1 | 105.2 | 71 | 31 | 31 | 13 | 42 | 83 | 6 | 0 | 0 | 2 | 9 | 1 | 0 | 4.26 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 78 | 13 | 13 | 6 | 3 | 3.26 | .285 | 1.19 | 6.1 | 4.5 | 8.0 | 91.0 | 62 | 34 | 33 | 8 | 46 | 81 | 1 | 0 | 0 | 0 | 8 | 1 | 0 | 3.91 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 86 | 25 | 0 | 0 | 1 | 3.33 | .289 | 1.22 | 8.3 | 2.7 | 8.3 | 27.0 | 25 | 10 | 10 | 2 | 8 | 25 | 0 | 8 | 2 | 0 | 0 | 0 | 1 | 3.00 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 75 | 10 | 0 | 1 | 1 | 2.25 | .294 | 1.25 | 5.6 | 5.6 | 13.5 | 8.0 | 5 | 2 | 2 | 2 | 5 | 12 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 5.13 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 84 | 5 | 0 | 1 | 0 | 4.05 | .333 | 1.50 | 13.5 | 1.5 | 9.0 | 6.2 | 9 | 3 | 3 | 1 | 1 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.67 |
| RP | Eichhorn, M.Eichhorn, Mark >> | 26 | 1986 | R | 49 | 6 | 0 | 1 | 0 | 1.50 | .194 | 0.72 | 4.0 | 2.5 | 7.0 | 18.0 | 8 | 3 | 3 | 1 | 5 | 14 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.00 |