| SP | Mussina, M.Mussina, Mike # >> | 38 | 2006 | R | 92 | 21 | 21 | 8 | 7 | 3.16 | .291 | 1.20 | 8.7 | 2.1 | 7.6 | 145.1 | 140 | 52 | 51 | 10 | 34 | 123 | 0 | 0 | 0 | 0 | 14 | 5 | 3 | 3.01 |
| SP | Schilling, C.Schilling, Curt >> | 40 | 2006 | R | 64 | 20 | 20 | 4 | 12 | 6.24 | .357 | 1.64 | 12.3 | 2.5 | 7.6 | 118.1 | 161 | 89 | 82 | 17 | 33 | 99 | 0 | 0 | 0 | 0 | 4 | 3 | 3 | 4.11 |
| SP | Francis, J.Francis, Jeff >> | 25 | 2006 | L | 57 | 20 | 20 | 5 | 12 | 5.30 | .330 | 1.44 | 9.0 | 3.9 | 6.8 | 124.0 | 124 | 75 | 73 | 20 | 54 | 93 | 1 | 0 | 0 | 0 | 8 | 5 | 0 | 5.02 |
| SP | Wakefield, T.Wakefield, Tim >> | 40 | 2006 | R | 46 | 20 | 20 | 7 | 6 | 4.72 | .329 | 1.44 | 9.6 | 3.5 | 5.6 | 127.2 | 135 | 71 | 67 | 19 | 49 | 79 | 0 | 0 | 0 | 0 | 10 | 4 | 4 | 4.95 |
| RP | Rodriguez, F.Rodriguez, Francisco >> | 24 | 2006 | R | 93 | 55 | 0 | 3 | 2 | 2.08 | .260 | 1.03 | 5.0 | 4.3 | 8.8 | 86.1 | 48 | 23 | 20 | 4 | 41 | 84 | 0 | 5 | 4 | 0 | 0 | 2 | 8 | 3.15 |
| RP | Betancourt, R.Betancourt, Rafael >> | 31 | 2006 | R | 70 | 54 | 0 | 0 | 5 | 4.73 | .306 | 1.31 | 9.5 | 2.3 | 8.5 | 70.1 | 74 | 42 | 37 | 15 | 18 | 66 | 0 | 5 | 3 | 0 | 0 | 1 | 0 | 4.71 |
| RP | Cassidy, S.Cassidy, Scott >> | 31 | 2006 | R | 32 | 34 | 0 | 2 | 2 | 4.97 | .317 | 1.37 | 9.5 | 2.8 | 9.5 | 38.0 | 40 | 21 | 21 | 5 | 12 | 40 | 0 | 7 | 1 | 0 | 0 | 1 | 0 | 3.63 |
| RP | Rincon, J.Rincon, Juan >> | 27 | 2006 | R | 21 | 29 | 0 | 4 | 3 | 7.86 | .387 | 1.81 | 13.2 | 3.2 | 8.2 | 34.1 | 50 | 30 | 30 | 8 | 12 | 31 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 5.56 |
| SP | Millwood, K.Millwood, Kevin >> | 32 | 2006 | R | 38 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Willis, D.Willis, Dontrelle >> | 24 | 2006 | L | 22 | 1 | 0 | 1 | 0 | 0.00 | .000 | 0.00 | 0.0 | 0.0 | 3.0 | 3.0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.33 |
| SP | Loaiza, E.Loaiza, Esteban >> | 35 | 2006 | R | 9 | 13 | 0 | 1 | 1 | 7.64 | .418 | 2.15 | 15.4 | 4.8 | 7.9 | 17.2 | 29 | 15 | 15 | 6 | 9 | 15 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 7.41 |