| SP | Santana, J.Santana, Johan >> | 27 | 2006 | L | 99 | 34 | 34 | 12 | 12 | 4.25 | .303 | 1.27 | 9.3 | 2.1 | 8.6 | 224.2 | 232 | 114 | 106 | 29 | 53 | 215 | 2 | 0 | 0 | 1 | 19 | 8 | 3 | 3.58 |
| SP | Peavy, J.Peavy, Jake # >> | 25 | 2006 | R | 87 | 30 | 30 | 14 | 13 | 5.59 | .350 | 1.58 | 10.2 | 4.1 | 8.9 | 164.1 | 185 | 110 | 102 | 23 | 74 | 163 | 0 | 0 | 0 | 0 | 12 | 6 | 2 | 4.30 |
| SP | Buchholz, T.Buchholz, Taylor >> | 25 | 2006 | R | 68 | 33 | 33 | 8 | 12 | 5.21 | .349 | 1.59 | 10.1 | 4.3 | 5.5 | 160.2 | 179 | 106 | 93 | 24 | 76 | 97 | 0 | 0 | 0 | 0 | 6 | 3 | 10 | 5.22 |
| SP | Beckett, J.Beckett, Josh # >> | 26 | 2006 | R | 62 | 32 | 32 | 8 | 10 | 5.24 | .321 | 1.37 | 9.6 | 2.8 | 6.0 | 190.2 | 202 | 118 | 111 | 21 | 59 | 126 | 1 | 0 | 0 | 1 | 13 | 9 | 10 | 4.18 |
| SP | Wakefield, T.Wakefield, Tim >> | 40 | 2006 | R | 46 | 32 | 32 | 7 | 15 | 6.03 | .353 | 1.57 | 10.8 | 3.4 | 5.5 | 183.2 | 220 | 128 | 123 | 37 | 69 | 111 | 1 | 0 | 0 | 1 | 11 | 11 | 3 | 5.73 |
| RP | Cordero, C.Cordero, Chad >> | 24 | 2006 | R | 83 | 91 | 0 | 6 | 2 | 2.51 | .263 | 1.03 | 6.7 | 2.6 | 6.9 | 125.1 | 93 | 42 | 35 | 18 | 36 | 96 | 0 | 3 | 5 | 0 | 0 | 5 | 0 | 4.32 |
| RP | Wainwright, A.Wainwright, Adam >> | 25 | 2006 | R | 79 | 89 | 0 | 7 | 1 | 5.09 | .310 | 1.30 | 8.1 | 3.6 | 6.3 | 116.2 | 105 | 71 | 66 | 18 | 47 | 81 | 0 | 0 | 2 | 0 | 0 | 5 | 8 | 4.97 |
| RP | Britton, C.Britton, Chris >> | 24 | 2006 | R | 68 | 63 | 0 | 5 | 3 | 2.82 | .294 | 1.21 | 8.4 | 2.6 | 6.4 | 70.1 | 65 | 24 | 22 | 9 | 20 | 50 | 0 | 1 | 5 | 0 | 0 | 3 | 0 | 4.23 |
| RP | Kensing, L.Kensing, Logan >> | 24 | 2006 | R | 57 | 43 | 0 | 3 | 0 | 4.53 | .310 | 1.31 | 7.9 | 4.0 | 9.9 | 49.2 | 43 | 27 | 25 | 3 | 22 | 54 | 0 | 2 | 0 | 0 | 0 | 2 | 0 | 3.06 |
| CL | Meredith, C.Meredith, Cla † >> | 23 | 2006 | R | 95 | 68 | 0 | 8 | 3 | 2.23 | .233 | 0.86 | 5.4 | 2.4 | 5.2 | 76.2 | 46 | 19 | 19 | 9 | 20 | 44 | 0 | 31 | 4 | 0 | 0 | 4 | 0 | 4.33 |