| SP | Clemens, R.Clemens, Roger $$ >> | 44 | 2006 | R | 97 | 34 | 34 | 12 | 9 | 3.27 | .287 | 1.18 | 7.7 | 3.0 | 6.3 | 192.2 | 164 | 73 | 70 | 14 | 64 | 134 | 1 | 0 | 0 | 1 | 11 | 5 | 5 | 3.63 |
| SP | Hamels, C.Hamels, Cole # >> | 23 | 2006 | L | 83 | 33 | 33 | 12 | 8 | 4.82 | .322 | 1.38 | 9.3 | 3.2 | 8.9 | 171.2 | 177 | 97 | 92 | 32 | 60 | 169 | 0 | 0 | 0 | 0 | 10 | 8 | 5 | 4.65 |
| SP | Johnson, R.Johnson, Randy † # >> | 43 | 2006 | L | 73 | 32 | 32 | 17 | 7 | 4.18 | .299 | 1.24 | 8.3 | 2.9 | 6.6 | 194.0 | 178 | 94 | 90 | 19 | 62 | 142 | 1 | 0 | 0 | 0 | 18 | 8 | 5 | 3.89 |
| SP | Escobar, K.Escobar, Kelvim >> | 30 | 2006 | R | 53 | 30 | 30 | 9 | 9 | 5.40 | .349 | 1.58 | 10.9 | 3.3 | 6.1 | 173.1 | 210 | 108 | 104 | 23 | 63 | 117 | 1 | 0 | 0 | 0 | 13 | 6 | 8 | 4.57 |
| SU | Zumaya, J.Zumaya, Joel >> | 22 | 2006 | R | 87 | 73 | 0 | 5 | 3 | 4.33 | .347 | 1.57 | 8.3 | 5.8 | 9.2 | 79.0 | 73 | 39 | 38 | 6 | 51 | 81 | 0 | 4 | 1 | 0 | 0 | 2 | 3 | 3.95 |
| RP | Rodney, F.Rodney, Fernando $$ >> | 29 | 2006 | R | 81 | 97 | 0 | 9 | 1 | 3.40 | .304 | 1.30 | 7.3 | 4.5 | 7.2 | 100.2 | 81 | 40 | 38 | 7 | 50 | 80 | 0 | 1 | 4 | 0 | 0 | 1 | 5 | 3.84 |
| RP | Wheeler, D.Wheeler, Dan >> | 29 | 2006 | R | 80 | 77 | 0 | 9 | 1 | 3.67 | .275 | 1.14 | 7.2 | 3.0 | 8.1 | 81.0 | 65 | 33 | 33 | 8 | 27 | 73 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 3.48 |
| RP | Oliver, D.Oliver, Darren >> | 36 | 2006 | L | 73 | 105 | 0 | 5 | 3 | 4.01 | .334 | 1.47 | 9.7 | 3.6 | 5.9 | 76.1 | 82 | 36 | 34 | 8 | 30 | 50 | 0 | 1 | 4 | 0 | 0 | 3 | 1 | 4.36 |
| RP | Qualls, C.Qualls, Chad >> | 28 | 2006 | R | 66 | 56 | 0 | 6 | 1 | 4.08 | .304 | 1.28 | 7.9 | 3.7 | 5.1 | 64.0 | 56 | 29 | 29 | 8 | 26 | 36 | 0 | 0 | 2 | 0 | 0 | 2 | 0 | 4.81 |
| RP | Walker, J.Walker, Jamie >> | 35 | 2006 | L | 58 | 80 | 0 | 5 | 2 | 3.92 | .262 | 1.05 | 7.4 | 2.2 | 5.9 | 66.2 | 54 | 29 | 29 | 9 | 16 | 43 | 0 | 4 | 2 | 0 | 0 | 1 | 1 | 4.24 |