| SP | Martinez, P.Martinez, Pedro >> | 35 | 2006 | R | 96 | 6 | 6 | 3 | 1 | 5.46 | .354 | 1.54 | 10.6 | 3.2 | 8.0 | 28.0 | 33 | 17 | 17 | 4 | 10 | 25 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 4.46 |
| SP | Sabathia, C.Sabathia, CC >> | 26 | 2006 | L | 85 | 5 | 5 | 3 | 0 | 4.86 | .346 | 1.53 | 11.5 | 2.5 | 7.6 | 33.1 | 42 | 18 | 18 | 6 | 9 | 28 | 0 | 0 | 0 | 0 | 2 | 2 | 0 | 4.67 |
| SP | Kazmir, S.Kazmir, Scott $ >> | 22 | 2006 | L | 75 | 5 | 5 | 3 | 2 | 2.94 | .289 | 1.16 | 6.3 | 4.4 | 7.1 | 33.2 | 23 | 11 | 11 | 4 | 16 | 26 | 0 | 0 | 0 | 0 | 4 | 2 | 1 | 4.64 |
| SP | Harang, A.Harang, Aaron >> | 28 | 2006 | R | 59 | 5 | 5 | 2 | 2 | 3.38 | .319 | 1.34 | 9.6 | 2.5 | 6.5 | 32.0 | 34 | 13 | 12 | 1 | 9 | 23 | 0 | 0 | 0 | 0 | 4 | 2 | 3 | 3.00 |
| SP | Bonderman, J.Bonderman, Jeremy >> | 24 | 2006 | R | 55 | 5 | 5 | 3 | 0 | 4.55 | .350 | 1.58 | 11.5 | 3.1 | 6.5 | 29.2 | 37 | 15 | 15 | 3 | 10 | 21 | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 4.03 |
| CL | Wagner, B.Wagner, Billy >> | 35 | 2006 | L | 86 | 13 | 0 | 1 | 0 | 0.68 | .259 | 1.05 | 6.9 | 2.8 | 9.7 | 13.1 | 10 | 3 | 1 | 1 | 4 | 14 | 0 | 8 | 1 | 0 | 0 | 0 | 0 | 2.77 |
| SU | Rivera, M.Rivera, Mariano >> | 37 | 2006 | R | 86 | 10 | 0 | 1 | 0 | 3.97 | .190 | 0.71 | 5.7 | 0.8 | 9.0 | 11.1 | 7 | 5 | 5 | 2 | 1 | 11 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 3.64 |
| RP | League, B.League, Brandon >> | 23 | 2006 | R | 82 | 11 | 0 | 1 | 0 | 3.00 | .294 | 1.25 | 9.8 | 1.5 | 5.3 | 12.0 | 13 | 4 | 4 | 0 | 2 | 7 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.33 |
| RP | Saito, T.Saito, Takashi >> | 36 | 2006 | R | 97 | 13 | 0 | 0 | 1 | 1.93 | .311 | 1.29 | 9.6 | 1.9 | 7.7 | 14.0 | 15 | 6 | 3 | 1 | 3 | 12 | 0 | 2 | 0 | 0 | 0 | 1 | 1 | 3.07 |
| RP | Weathers, D.Weathers, Dave >> | 37 | 2006 | R | 49 | 5 | 0 | 1 | 0 | 0.00 | .278 | 1.15 | 4.5 | 6.8 | 9.0 | 4.1 | 2 | 0 | 0 | 0 | 3 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.25 |
| RP | Bradford, C.Bradford, Chad >> | 32 | 2006 | R | 53 | 7 | 0 | 1 | 0 | 3.24 | .242 | 0.96 | 7.9 | 1.1 | 6.8 | 8.1 | 7 | 3 | 3 | 1 | 1 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.50 |
| RP | Heilman, A.Heilman, Aaron >> | 28 | 2006 | R | 74 | 4 | 0 | 1 | 0 | 5.40 | .333 | 1.50 | 9.0 | 6.0 | 18.0 | 3.1 | 3 | 2 | 2 | 0 | 2 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.00 |
| RP | Thornton, M.Thornton, Matt >> | 30 | 2006 | L | 67 | 14 | 0 | 0 | 0 | 3.45 | .309 | 1.28 | 7.8 | 4.2 | 4.8 | 15.2 | 13 | 6 | 6 | 2 | 7 | 8 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 5.27 |