| SP | Martinez, P.Martinez, Pedro † >> | 35 | 2006 | R | 96 | 33 | 33 | 14 | 7 | 3.93 | .316 | 1.34 | 9.7 | 2.4 | 7.8 | 174.0 | 188 | 83 | 76 | 16 | 46 | 151 | 0 | 0 | 0 | 0 | 7 | 7 | 1 | 3.37 |
| SP | Sabathia, C.Sabathia, CC >> | 26 | 2006 | L | 85 | 33 | 33 | 18 | 10 | 4.82 | .336 | 1.49 | 10.5 | 3.0 | 6.4 | 214.2 | 249 | 122 | 115 | 21 | 71 | 151 | 2 | 0 | 0 | 1 | 16 | 6 | 9 | 3.94 |
| SP | Kazmir, S.Kazmir, Scott † $ >> | 22 | 2006 | L | 75 | 32 | 32 | 20 | 8 | 4.04 | .319 | 1.37 | 8.9 | 3.4 | 9.0 | 196.0 | 193 | 91 | 88 | 23 | 75 | 195 | 2 | 0 | 0 | 1 | 19 | 8 | 5 | 3.81 |
| SP | Harang, A.Harang, Aaron # >> | 28 | 2006 | R | 59 | 32 | 32 | 7 | 12 | 5.40 | .343 | 1.52 | 10.2 | 3.5 | 6.7 | 186.2 | 211 | 117 | 112 | 22 | 72 | 139 | 0 | 0 | 0 | 0 | 13 | 10 | 6 | 4.37 |
| SP | Bonderman, J.Bonderman, Jeremy # >> | 24 | 2006 | R | 55 | 31 | 31 | 9 | 6 | 6.37 | .371 | 1.74 | 12.2 | 3.5 | 7.6 | 169.2 | 229 | 123 | 120 | 29 | 66 | 143 | 1 | 0 | 0 | 0 | 10 | 5 | 4 | 4.80 |
| CL | Saito, T.Saito, Takashi >> | 36 | 2006 | R | 97 | 60 | 0 | 6 | 3 | 3.68 | .320 | 1.39 | 8.3 | 4.2 | 8.7 | 66.0 | 61 | 30 | 27 | 6 | 31 | 64 | 0 | 18 | 5 | 0 | 0 | 1 | 2 | 3.70 |
| SU | League, B.League, Brandon >> | 23 | 2006 | R | 82 | 82 | 0 | 6 | 2 | 3.47 | .307 | 1.33 | 9.5 | 2.5 | 5.3 | 85.2 | 90 | 36 | 33 | 5 | 24 | 50 | 0 | 1 | 4 | 0 | 0 | 0 | 0 | 3.44 |
| RP | Thornton, M.Thornton, Matt >> | 30 | 2006 | L | 67 | 90 | 0 | 3 | 1 | 3.26 | .343 | 1.52 | 9.1 | 4.6 | 7.0 | 69.0 | 70 | 26 | 25 | 10 | 35 | 54 | 0 | 1 | 2 | 0 | 0 | 3 | 0 | 4.97 |
| RP | Heilman, A.Heilman, Aaron >> | 28 | 2006 | R | 74 | 51 | 0 | 1 | 1 | 3.50 | .280 | 1.15 | 6.8 | 3.5 | 8.0 | 54.0 | 41 | 21 | 21 | 1 | 21 | 48 | 0 | 0 | 2 | 0 | 0 | 1 | 2 | 2.69 |
| RP | Bradford, C.Bradford, Chad >> | 32 | 2006 | R | 53 | 57 | 0 | 5 | 5 | 3.92 | .298 | 1.26 | 9.0 | 2.4 | 6.5 | 64.1 | 64 | 30 | 28 | 5 | 17 | 46 | 0 | 1 | 2 | 0 | 0 | 1 | 0 | 3.42 |
| RP | Wagner, B.Wagner, Billy † >> | 35 | 2006 | L | 86 | 70 | 0 | 5 | 3 | 4.21 | .337 | 1.49 | 10.6 | 2.9 | 9.7 | 68.1 | 80 | 34 | 32 | 10 | 22 | 73 | 0 | 23 | 6 | 0 | 0 | 2 | 4 | 3.82 |
| RP | Rivera, M.Rivera, Mariano >> | 37 | 2006 | R | 86 | 43 | 0 | 1 | 2 | 4.23 | .309 | 1.32 | 9.0 | 3.1 | 7.0 | 44.2 | 44 | 21 | 21 | 7 | 15 | 34 | 0 | 2 | 3 | 0 | 0 | 1 | 0 | 4.61 |
| RP | Weathers, D.Weathers, Dave >> | 37 | 2006 | R | 49 | 56 | 0 | 4 | 2 | 4.01 | .338 | 1.50 | 7.8 | 5.9 | 6.2 | 60.2 | 52 | 28 | 27 | 8 | 39 | 41 | 0 | 2 | 2 | 0 | 0 | 2 | 0 | 5.42 |