| SP | Santana, J.Santana, Johan $ >> | 27 | 2006 | L | 99 | 16 | 16 | 7 | 6 | 4.47 | .305 | 1.27 | 8.5 | 3.0 | 8.4 | 102.2 | 96 | 51 | 51 | 13 | 34 | 95 | 0 | 0 | 0 | 0 | 9 | 5 | 3 | 3.94 |
| SP | Sabathia, C.Sabathia, CC $ >> | 26 | 2006 | L | 85 | 16 | 16 | 8 | 5 | 5.05 | .324 | 1.44 | 9.8 | 3.2 | 7.6 | 101.2 | 110 | 59 | 57 | 18 | 36 | 85 | 0 | 0 | 0 | 0 | 8 | 0 | 0 | 4.70 |
| SP | Schmidt, J.Schmidt, Jason >> | 33 | 2006 | R | 74 | 16 | 16 | 7 | 4 | 4.22 | .341 | 1.54 | 9.4 | 4.6 | 7.4 | 89.2 | 93 | 46 | 42 | 7 | 45 | 73 | 1 | 0 | 0 | 1 | 9 | 1 | 3 | 3.93 |
| SP | Myers, B.Myers, Brett # >> | 26 | 2006 | R | 63 | 16 | 16 | 9 | 7 | 5.33 | .322 | 1.38 | 9.9 | 2.5 | 8.9 | 96.1 | 106 | 57 | 57 | 12 | 27 | 95 | 0 | 0 | 0 | 0 | 7 | 4 | 4 | 3.61 |
| SP | Escobar, K.Escobar, Kelvim >> | 30 | 2006 | R | 53 | 16 | 16 | 9 | 5 | 3.73 | .293 | 1.19 | 7.8 | 3.0 | 6.3 | 103.2 | 89 | 44 | 43 | 15 | 34 | 72 | 1 | 0 | 0 | 1 | 11 | 6 | 2 | 4.66 |
| CL | Hoffman, T.Hoffman, Trevor >> | 39 | 2006 | R | 91 | 31 | 0 | 3 | 3 | 2.01 | .242 | 0.93 | 5.5 | 2.9 | 7.8 | 31.1 | 19 | 10 | 7 | 1 | 10 | 27 | 0 | 23 | 3 | 0 | 0 | 1 | 0 | 2.74 |
| SU | Wagner, B.Wagner, Billy >> | 35 | 2006 | L | 86 | 32 | 0 | 0 | 0 | 2.41 | .263 | 1.04 | 5.8 | 3.6 | 8.5 | 37.1 | 24 | 11 | 10 | 3 | 15 | 35 | 0 | 3 | 1 | 0 | 0 | 1 | 0 | 3.46 |
| RP | Broxton, J.Broxton, Jonathan >> | 22 | 2006 | R | 78 | 39 | 0 | 1 | 1 | 2.08 | .255 | 1.00 | 5.3 | 3.7 | 9.0 | 39.0 | 23 | 9 | 9 | 5 | 16 | 39 | 0 | 0 | 2 | 0 | 0 | 1 | 2 | 3.97 |
| RP | Calero, K.Calero, Kiko >> | 31 | 2006 | R | 62 | 24 | 0 | 0 | 1 | 2.25 | .184 | 0.68 | 3.2 | 2.9 | 10.6 | 28.0 | 10 | 7 | 7 | 2 | 9 | 33 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2.54 |
| RP | Gonzalez, M.Gonzalez, Mike >> | 28 | 2006 | L | 56 | 26 | 0 | 0 | 0 | 1.93 | .273 | 1.02 | 8.5 | 1.0 | 8.0 | 18.2 | 17 | 4 | 4 | 1 | 2 | 16 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 2.61 |
| RP | Thornton, M.Thornton, Matt >> | 30 | 2006 | L | 67 | 35 | 0 | 0 | 1 | 4.32 | .348 | 1.56 | 9.4 | 4.7 | 6.1 | 25.0 | 26 | 12 | 12 | 1 | 13 | 17 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 3.84 |
| RP | Zumaya, J.Zumaya, Joel >> | 22 | 2006 | R | 87 | 24 | 0 | 1 | 0 | 6.04 | .345 | 1.58 | 8.6 | 5.8 | 10.8 | 25.1 | 24 | 17 | 17 | 2 | 16 | 30 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.56 |
| RP | Ramirez, R.Ramirez, Ramon >> | 25 | 2006 | R | 58 | 22 | 0 | 2 | 0 | 7.31 | .368 | 1.75 | 12.4 | 3.4 | 7.3 | 16.0 | 22 | 13 | 13 | 4 | 6 | 13 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.75 |