| SP | Santana, J.Santana, Johan >> | 27 | 2006 | L | 99 | 9 | 9 | 3 | 3 | 3.62 | .295 | 1.26 | 10.1 | 1.4 | 8.5 | 59.2 | 66 | 24 | 24 | 6 | 9 | 56 | 1 | 0 | 0 | 0 | 5 | 0 | 2 | 2.88 |
| SP | Sabathia, C.Sabathia, CC # >> | 26 | 2006 | L | 85 | 8 | 8 | 4 | 4 | 5.55 | .344 | 1.55 | 10.3 | 3.6 | 7.1 | 47.0 | 54 | 33 | 29 | 4 | 19 | 37 | 0 | 0 | 0 | 0 | 3 | 1 | 0 | 3.81 |
| SP | Kazmir, S.Kazmir, Scott >> | 22 | 2006 | L | 75 | 8 | 8 | 4 | 0 | 4.47 | .338 | 1.49 | 9.5 | 4.0 | 9.2 | 50.1 | 53 | 27 | 25 | 4 | 22 | 51 | 0 | 0 | 0 | 0 | 5 | 2 | 0 | 3.44 |
| SP | Schilling, C.Schilling, Curt >> | 40 | 2006 | R | 64 | 8 | 8 | 3 | 2 | 4.47 | .326 | 1.45 | 11.3 | 1.9 | 6.2 | 48.1 | 60 | 24 | 24 | 2 | 10 | 33 | 0 | 0 | 0 | 0 | 4 | 0 | 2 | 2.79 |
| CL | Papelbon, J.Papelbon, Jonathan $ >> | 26 | 2006 | R | 98 | 19 | 0 | 2 | 1 | 1.31 | .215 | 0.77 | 5.4 | 1.8 | 7.7 | 20.2 | 12 | 3 | 3 | 0 | 4 | 17 | 0 | 13 | 1 | 0 | 0 | 1 | 0 | 2.05 |
| SU | Broxton, J.Broxton, Jonathan >> | 22 | 2006 | R | 78 | 23 | 0 | 0 | 0 | 1.32 | .196 | 0.66 | 4.0 | 2.0 | 10.3 | 27.1 | 12 | 4 | 4 | 0 | 6 | 31 | 0 | 0 | 0 | 0 | 0 | 2 | 2 | 1.59 |
| RP | Thornton, M.Thornton, Matt >> | 30 | 2006 | L | 67 | 11 | 0 | 0 | 0 | 2.25 | .250 | 1.00 | 5.1 | 3.9 | 7.3 | 16.0 | 9 | 4 | 4 | 2 | 7 | 13 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.31 |
| RP | Carrasco, H.Carrasco, Hector >> | 37 | 2006 | R | 52 | 19 | 0 | 3 | 0 | 1.42 | .240 | 0.87 | 6.8 | 1.5 | 3.8 | 12.2 | 9 | 2 | 2 | 1 | 2 | 5 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 4.00 |
| RP | Gonzalez, M.Gonzalez, Mike >> | 28 | 2006 | L | 56 | 12 | 0 | 2 | 1 | 2.84 | .345 | 1.58 | 9.0 | 6.0 | 7.5 | 6.1 | 6 | 2 | 2 | 0 | 4 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.33 |
| RP | Wagner, B.Wagner, Billy >> | 35 | 2006 | L | 86 | 16 | 0 | 0 | 1 | 5.29 | .282 | 1.12 | 6.4 | 3.7 | 10.6 | 17.0 | 12 | 10 | 10 | 3 | 7 | 20 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 4.35 |
| RP | Valverde, J.Valverde, Jose >> | 27 | 2006 | R | 16 | 10 | 0 | 0 | 0 | 9.00 | .415 | 2.13 | 12.4 | 6.8 | 10.1 | 8.0 | 11 | 8 | 8 | 3 | 6 | 9 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 7.88 |