| SP | Mussina, M.Mussina, Mike † >> | 38 | 2006 | R | 92 | 34 | 34 | 18 | 9 | 3.73 | .297 | 1.25 | 9.0 | 2.3 | 7.1 | 219.2 | 220 | 92 | 91 | 23 | 55 | 172 | 1 | 0 | 0 | 0 | 22 | 4 | 4 | 3.60 |
| SP | Smoltz, J.Smoltz, John >> | 39 | 2006 | R | 82 | 33 | 33 | 9 | 10 | 4.70 | .338 | 1.51 | 10.8 | 2.9 | 6.9 | 216.1 | 258 | 125 | 113 | 29 | 69 | 166 | 3 | 0 | 0 | 1 | 17 | 4 | 10 | 4.22 |
| SP | Zambrano, C.Zambrano, Carlos $$ >> | 25 | 2006 | R | 77 | 31 | 31 | 15 | 9 | 4.78 | .324 | 1.40 | 8.3 | 4.3 | 5.5 | 184.2 | 170 | 102 | 98 | 27 | 88 | 113 | 0 | 0 | 0 | 0 | 20 | 8 | 4 | 5.24 |
| SP | Cain, M.Cain, Matt † $ >> | 22 | 2006 | R | 76 | 32 | 32 | 17 | 5 | 4.13 | .313 | 1.33 | 8.0 | 4.0 | 6.1 | 174.1 | 155 | 88 | 80 | 14 | 77 | 117 | 0 | 0 | 0 | 0 | 11 | 6 | 6 | 4.13 |
| RP | Gonzalez, M.Gonzalez, Mike † >> | 28 | 2006 | L | 56 | 82 | 0 | 10 | 4 | 2.86 | .310 | 1.27 | 6.6 | 4.9 | 10.5 | 94.1 | 69 | 32 | 30 | 7 | 51 | 110 | 0 | 3 | 3 | 0 | 0 | 7 | 0 | 3.48 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 26 | 2006 | R | 98 | 88 | 0 | 5 | 7 | 3.90 | .285 | 1.16 | 8.1 | 2.4 | 8.2 | 115.1 | 103 | 54 | 50 | 14 | 31 | 105 | 0 | 10 | 6 | 0 | 0 | 4 | 5 | 3.67 |
| RP | Fuentes, B.Fuentes, Brian >> | 31 | 2006 | L | 84 | 72 | 0 | 5 | 1 | 2.75 | .274 | 1.09 | 7.3 | 2.6 | 9.1 | 91.2 | 74 | 28 | 28 | 7 | 26 | 92 | 0 | 12 | 3 | 0 | 0 | 4 | 7 | 2.97 |
| RP | Broxton, J.Broxton, Jonathan >> | 22 | 2006 | R | 78 | 42 | 0 | 5 | 3 | 2.22 | .238 | 0.90 | 5.3 | 2.9 | 11.1 | 56.2 | 33 | 15 | 14 | 5 | 18 | 69 | 0 | 5 | 0 | 0 | 0 | 2 | 0 | 2.77 |
| RP | Aardsma, D.Aardsma, David >> | 25 | 2006 | R | 63 | 35 | 0 | 1 | 3 | 4.78 | .289 | 1.19 | 7.8 | 3.2 | 7.5 | 37.2 | 32 | 20 | 20 | 9 | 13 | 31 | 0 | 8 | 2 | 0 | 0 | 1 | 0 | 5.62 |
| RP | Correia, K.Correia, Kevin >> | 26 | 2006 | R | 51 | 30 | 0 | 3 | 2 | 2.38 | .271 | 1.12 | 7.4 | 2.6 | 8.5 | 34.0 | 28 | 13 | 9 | 4 | 10 | 32 | 0 | 5 | 2 | 0 | 0 | 0 | 0 | 3.53 |
| RP | Calero, K.Calero, Kiko >> | 31 | 2006 | R | 62 | 38 | 0 | 1 | 0 | 3.91 | .343 | 1.54 | 9.0 | 4.9 | 7.2 | 46.0 | 46 | 20 | 20 | 6 | 25 | 37 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 4.78 |