| SP | Mussina, M.Mussina, Mike >> | 38 | 2006 | R | 92 | 16 | 16 | 8 | 5 | 3.98 | .267 | 1.10 | 8.2 | 1.8 | 7.0 | 108.2 | 98 | 51 | 48 | 10 | 21 | 84 | 2 | 0 | 0 | 0 | 8 | 0 | 0 | 3.23 |
| SP | Halladay, R.Halladay, Roy >> | 29 | 2006 | R | 84 | 16 | 16 | 9 | 3 | 2.75 | .268 | 1.06 | 8.1 | 1.5 | 5.9 | 111.1 | 100 | 37 | 34 | 10 | 18 | 73 | 0 | 0 | 0 | 0 | 12 | 4 | 3 | 3.45 |
| SP | Arroyo, B.Arroyo, Bronson >> | 29 | 2006 | R | 81 | 16 | 16 | 7 | 2 | 3.86 | .298 | 1.22 | 8.4 | 2.6 | 6.1 | 98.0 | 92 | 44 | 42 | 12 | 28 | 66 | 1 | 0 | 0 | 1 | 10 | 5 | 1 | 4.26 |
| SP | Beckett, J.Beckett, Josh >> | 26 | 2006 | R | 62 | 16 | 16 | 7 | 4 | 4.82 | .346 | 1.55 | 10.0 | 3.9 | 6.5 | 97.0 | 108 | 53 | 52 | 14 | 42 | 70 | 0 | 0 | 0 | 0 | 7 | 4 | 4 | 4.86 |
| RP | Fuentes, B.Fuentes, Brian >> | 31 | 2006 | L | 84 | 38 | 0 | 4 | 2 | 4.01 | .248 | 0.97 | 5.6 | 3.2 | 9.9 | 51.2 | 32 | 24 | 23 | 4 | 18 | 56 | 0 | 10 | 1 | 0 | 0 | 1 | 1 | 2.94 |
| RP | Oliver, D.Oliver, Darren >> | 36 | 2006 | L | 73 | 30 | 0 | 1 | 3 | 3.03 | .296 | 1.21 | 8.2 | 2.8 | 5.7 | 35.2 | 32 | 17 | 12 | 6 | 11 | 22 | 0 | 2 | 3 | 0 | 0 | 2 | 0 | 5.09 |
| RP | Wuertz, M.Wuertz, Michael >> | 28 | 2006 | R | 59 | 12 | 0 | 1 | 0 | 3.75 | .379 | 1.83 | 9.8 | 6.8 | 8.3 | 12.0 | 13 | 5 | 5 | 0 | 9 | 11 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 3.42 |
| RP | Heilman, A.Heilman, Aaron >> | 28 | 2006 | R | 74 | 18 | 0 | 0 | 0 | 4.50 | .318 | 1.40 | 10.8 | 1.8 | 6.8 | 20.0 | 24 | 10 | 10 | 2 | 4 | 15 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.40 |