| SP | Mussina, M.Mussina, Mike >> | 38 | 2006 | R | 92 | 9 | 9 | 3 | 4 | 3.25 | .296 | 1.23 | 9.3 | 1.8 | 6.2 | 61.0 | 63 | 28 | 22 | 6 | 12 | 42 | 1 | 0 | 0 | 0 | 6 | 2 | 1 | 3.59 |
| SP | Sanchez, A.Sanchez, Anibal $ >> | 22 | 2006 | R | 88 | 9 | 9 | 5 | 2 | 4.17 | .306 | 1.30 | 7.6 | 4.2 | 5.7 | 58.1 | 49 | 27 | 27 | 5 | 27 | 37 | 0 | 0 | 0 | 0 | 4 | 1 | 2 | 4.29 |
| SP | Schmidt, J.Schmidt, Jason # >> | 33 | 2006 | R | 74 | 8 | 8 | 3 | 3 | 5.10 | .306 | 1.26 | 7.5 | 4.0 | 5.7 | 47.2 | 39 | 27 | 27 | 5 | 21 | 30 | 0 | 0 | 0 | 0 | 4 | 3 | 4 | 4.64 |
| SP | Beckett, J.Beckett, Josh >> | 26 | 2006 | R | 62 | 8 | 8 | 1 | 4 | 4.93 | .357 | 1.66 | 12.1 | 2.9 | 6.1 | 49.1 | 66 | 27 | 27 | 8 | 16 | 33 | 0 | 0 | 0 | 0 | 3 | 0 | 2 | 4.76 |
| SP | Maddux, G.Maddux, Greg >> | 40 | 2006 | R | 56 | 6 | 5 | 4 | 1 | 3.41 | .346 | 1.59 | 11.5 | 2.8 | 5.3 | 29.0 | 37 | 11 | 11 | 1 | 9 | 17 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.21 |
| RP | Cordero, C.Cordero, Chad >> | 24 | 2006 | R | 83 | 23 | 0 | 0 | 0 | 1.62 | .180 | 0.66 | 4.1 | 1.9 | 6.3 | 33.1 | 15 | 7 | 6 | 0 | 7 | 23 | 0 | 6 | 0 | 0 | 0 | 0 | 0 | 2.24 |
| RP | Duchscherer, J.Duchscherer, Justin >> | 29 | 2006 | R | 71 | 16 | 0 | 2 | 2 | 1.66 | .244 | 0.97 | 7.7 | 1.3 | 9.9 | 21.2 | 18 | 4 | 4 | 1 | 3 | 23 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1.86 |
| RP | Betancourt, R.Betancourt, Rafael >> | 31 | 2006 | R | 70 | 12 | 0 | 2 | 0 | 3.48 | .311 | 1.26 | 9.0 | 2.7 | 9.9 | 10.1 | 10 | 4 | 4 | 1 | 3 | 11 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 3.30 |
| RP | Qualls, C.Qualls, Chad >> | 28 | 2006 | R | 66 | 4 | 0 | 0 | 0 | 1.59 | .261 | 1.06 | 3.6 | 7.2 | 10.8 | 5.2 | 2 | 1 | 1 | 0 | 4 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.00 |
| RP | Calero, K.Calero, Kiko >> | 31 | 2006 | R | 62 | 5 | 0 | 0 | 0 | 3.86 | .263 | 0.86 | 9.0 | 0.0 | 6.8 | 4.2 | 4 | 2 | 2 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 2.25 |
| RP | Kensing, L.Kensing, Logan >> | 24 | 2006 | R | 57 | 4 | 0 | 0 | 0 | 2.08 | .235 | 0.92 | 6.8 | 2.3 | 11.3 | 4.1 | 3 | 1 | 1 | 0 | 1 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.25 |