| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 33 | 33 | 13 | 15 | 3.42 | .281 | 1.14 | 7.3 | 2.9 | 8.9 | 226.0 | 184 | 98 | 86 | 28 | 74 | 223 | 1 | 0 | 0 | 1 | 21 | 7 | 0 | 3.71 |
| SP | Pfiester, J.Pfiester, Jack >> | 28 | 1906 | L | 74 | 32 | 32 | 15 | 9 | 4.22 | .319 | 1.39 | 8.5 | 3.9 | 4.8 | 196.1 | 186 | 97 | 92 | 19 | 86 | 104 | 5 | 0 | 0 | 2 | 16 | 4 | 2 | 4.58 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 84 | 31 | 31 | 10 | 6 | 4.84 | .305 | 1.29 | 9.9 | 1.8 | 5.0 | 158.0 | 173 | 85 | 85 | 27 | 31 | 87 | 0 | 0 | 0 | 0 | 10 | 4 | 5 | 4.78 |
| SP | Chesbro, J.Chesbro, Jack >> | 30 | 1904 | R | 65 | 30 | 30 | 13 | 11 | 4.33 | .301 | 1.28 | 8.0 | 3.5 | 4.6 | 189.1 | 168 | 96 | 91 | 21 | 74 | 96 | 4 | 0 | 0 | 1 | 15 | 3 | 7 | 4.65 |
| RP | Kimbrel, C.Kimbrel, Craig † >> | 24 | 2012 | R | 100 | 77 | 0 | 5 | 2 | 3.10 | .275 | 1.11 | 5.9 | 4.2 | 10.3 | 104.2 | 68 | 39 | 36 | 4 | 48 | 119 | 0 | 8 | 2 | 0 | 0 | 3 | 3 | 2.68 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 71 | 0 | 5 | 4 | 3.52 | .276 | 1.15 | 7.1 | 3.3 | 7.7 | 107.1 | 84 | 42 | 42 | 13 | 39 | 91 | 0 | 9 | 1 | 0 | 0 | 0 | 1 | 3.97 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 55 | 0 | 5 | 4 | 4.06 | .299 | 1.27 | 8.0 | 3.4 | 7.6 | 71.0 | 63 | 32 | 32 | 5 | 27 | 60 | 0 | 8 | 3 | 0 | 0 | 1 | 0 | 3.41 |
| RP | Wilhelm, H.Wilhelm, Hoyt >> | 43 | 1965 | R | 68 | 35 | 0 | 2 | 7 | 3.57 | .264 | 1.08 | 7.0 | 2.7 | 4.9 | 53.0 | 41 | 21 | 21 | 5 | 16 | 29 | 0 | 3 | 0 | 0 | 0 | 0 | 6 | 4.04 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 73 | 26 | 0 | 1 | 0 | 3.51 | .270 | 1.11 | 7.6 | 2.5 | 4.9 | 33.1 | 28 | 13 | 13 | 3 | 9 | 18 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.91 |
| SP | Perry, G.Perry, Gaylord >> | 34 | 1972 | R | 54 | 8 | 0 | 0 | 2 | 21.27 | .529 | 3.27 | 23.7 | 5.7 | 3.3 | 11.0 | 29 | 26 | 26 | 2 | 7 | 4 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 6.82 |