| SP | Chesbro, J.Chesbro, Jack >> | 30 | 1904 | R | 65 | 24 | 11 | 4 | 7 | 5.33 | .336 | 1.50 | 9.8 | 3.7 | 4.5 | 130.0 | 142 | 94 | 77 | 21 | 53 | 65 | 1 | 0 | 0 | 0 | 4 | 2 | 4 | 5.37 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 79 | 29 | 28 | 10 | 14 | 5.62 | .335 | 1.50 | 10.6 | 2.9 | 4.8 | 182.2 | 215 | 123 | 114 | 18 | 59 | 98 | 3 | 0 | 0 | 0 | 10 | 2 | 2 | 4.21 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 74 | 32 | 32 | 13 | 15 | 4.42 | .311 | 1.33 | 9.3 | 2.7 | 4.4 | 213.2 | 221 | 124 | 105 | 17 | 64 | 103 | 6 | 0 | 0 | 1 | 18 | 5 | 3 | 4.04 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 71 | 0 | 3 | 7 | 3.08 | .263 | 1.06 | 8.4 | 1.2 | 7.8 | 87.2 | 81 | 35 | 30 | 9 | 12 | 75 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 3.07 |
| RP | Wagner, B.Wagner, Billy † # >> | 28 | 1999 | L | 95 | 54 | 0 | 6 | 5 | 4.50 | .323 | 1.41 | 8.4 | 4.3 | 9.3 | 56.0 | 52 | 30 | 28 | 8 | 27 | 58 | 0 | 27 | 7 | 0 | 0 | 1 | 2 | 4.29 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 82 | 38 | 0 | 3 | 0 | 1.99 | .252 | 0.98 | 5.6 | 3.4 | 8.1 | 40.2 | 25 | 9 | 9 | 5 | 15 | 36 | 0 | 1 | 0 | 0 | 0 | 1 | 3 | 4.03 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 25 | 0 | 1 | 1 | 3.33 | .302 | 1.30 | 7.0 | 4.7 | 8.0 | 27.0 | 21 | 11 | 10 | 2 | 14 | 24 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 3.74 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 73 | 29 | 0 | 1 | 2 | 4.00 | .312 | 1.33 | 9.5 | 2.5 | 8.0 | 36.0 | 38 | 18 | 16 | 3 | 10 | 32 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.22 |
| SP | Leonard, D.Leonard, Dutch # >> | 22 | 1914 | L | 91 | 31 | 31 | 11 | 9 | 4.33 | .282 | 1.16 | 7.8 | 2.6 | 5.5 | 199.1 | 173 | 107 | 96 | 21 | 58 | 121 | 3 | 0 | 0 | 1 | 15 | 4 | 4 | 4.09 |
| SP | Fernandez, S.Fernandez, Sid >> | 23 | 1985 | L | 49 | 26 | 26 | 11 | 8 | 4.22 | .322 | 1.41 | 8.5 | 4.3 | 8.1 | 164.1 | 154 | 90 | 77 | 22 | 78 | 148 | 0 | 0 | 0 | 0 | 14 | 2 | 2 | 4.40 |