| SP | McNally, D.McNally, Dave >> | 26 | 1968 | L | 96 | 34 | 34 | 15 | 14 | 3.68 | .289 | 1.20 | 7.9 | 2.9 | 5.3 | 262.0 | 229 | 122 | 107 | 24 | 85 | 153 | 12 | 0 | 0 | 3 | 20 | 5 | 5 | 4.05 |
| SP | Kluber, C.Kluber, Corey # >> | 31 | 2017 | R | 89 | 32 | 32 | 9 | 15 | 4.86 | .319 | 1.37 | 9.2 | 3.1 | 9.2 | 209.1 | 214 | 123 | 113 | 31 | 72 | 214 | 3 | 0 | 0 | 1 | 14 | 8 | 12 | 4.03 |
| SP | McLain, D.McLain, Denny # >> | 24 | 1968 | R | 78 | 32 | 32 | 19 | 11 | 4.23 | .285 | 1.18 | 8.7 | 1.9 | 5.7 | 238.1 | 231 | 119 | 112 | 28 | 51 | 150 | 15 | 0 | 0 | 3 | 16 | 3 | 5 | 3.95 |
| SP | Bender, C.Bender, Chief >> | 26 | 1910 | R | 71 | 31 | 31 | 8 | 21 | 5.63 | .340 | 1.53 | 10.4 | 3.4 | 5.1 | 199.2 | 229 | 137 | 125 | 29 | 76 | 112 | 3 | 0 | 0 | 0 | 10 | 4 | 8 | 4.97 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 78 | 0 | 4 | 2 | 3.60 | .293 | 1.23 | 7.9 | 3.2 | 7.5 | 90.0 | 79 | 41 | 36 | 18 | 32 | 75 | 0 | 4 | 2 | 0 | 0 | 1 | 4 | 5.03 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 84 | 28 | 0 | 3 | 0 | 2.70 | .254 | 1.02 | 4.1 | 5.2 | 9.5 | 33.1 | 15 | 10 | 10 | 4 | 19 | 35 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.18 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 77 | 14 | 0 | 1 | 2 | 4.20 | .262 | 0.93 | 7.8 | 0.6 | 3.6 | 15.0 | 13 | 7 | 7 | 1 | 1 | 6 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 3.67 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 76 | 11 | 0 | 0 | 1 | 2.77 | .235 | 0.92 | 5.5 | 2.8 | 10.4 | 13.0 | 8 | 4 | 4 | 2 | 4 | 15 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 3.62 |