| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 34 | 34 | 14 | 9 | 4.46 | .309 | 1.31 | 9.1 | 2.7 | 9.8 | 213.2 | 215 | 112 | 106 | 22 | 65 | 233 | 1 | 0 | 0 | 1 | 18 | 7 | 0 | 3.17 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 33 | 33 | 14 | 13 | 4.29 | .295 | 1.22 | 8.0 | 3.0 | 8.5 | 232.2 | 206 | 118 | 111 | 28 | 77 | 219 | 5 | 0 | 0 | 2 | 17 | 9 | 6 | 3.79 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 76 | 32 | 32 | 12 | 10 | 5.32 | .327 | 1.43 | 9.0 | 3.9 | 7.3 | 194.2 | 194 | 121 | 115 | 31 | 84 | 157 | 2 | 0 | 0 | 1 | 15 | 6 | 5 | 4.85 |
| SP | Bender, C.Bender, Chief # >> | 26 | 1910 | R | 72 | 32 | 32 | 9 | 17 | 5.40 | .327 | 1.43 | 10.0 | 2.9 | 4.2 | 235.0 | 260 | 151 | 141 | 29 | 76 | 110 | 8 | 0 | 0 | 0 | 10 | 6 | 6 | 4.71 |
| RP | Adams, M.Adams, Mike † >> | 31 | 2009 | R | 99 | 81 | 0 | 12 | 3 | 2.32 | .287 | 1.18 | 7.0 | 3.7 | 9.8 | 112.2 | 87 | 32 | 29 | 4 | 46 | 122 | 0 | 6 | 3 | 0 | 0 | 3 | 4 | 2.60 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 77 | 0 | 6 | 6 | 4.47 | .295 | 1.24 | 9.2 | 2.0 | 9.3 | 94.2 | 96 | 47 | 47 | 12 | 21 | 97 | 0 | 9 | 5 | 0 | 0 | 2 | 1 | 3.33 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 71 | 78 | 0 | 2 | 1 | 2.69 | .291 | 1.21 | 6.3 | 4.7 | 8.1 | 83.2 | 58 | 28 | 25 | 3 | 43 | 75 | 0 | 13 | 2 | 0 | 0 | 2 | 1 | 3.29 |
| RP | Valverde, J.Valverde, Jose # >> | 24 | 2003 | R | 64 | 44 | 0 | 2 | 4 | 4.97 | .340 | 1.53 | 9.0 | 4.8 | 8.2 | 54.1 | 54 | 34 | 30 | 4 | 29 | 49 | 0 | 3 | 4 | 0 | 0 | 1 | 3 | 3.81 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 58 | 3 | 0 | 0 | 0 | 0.00 | .400 | 2.00 | 9.0 | 9.0 | 9.0 | 1.0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.00 |