| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 6 | 6 | 2 | 3 | 4.65 | .282 | 1.16 | 8.3 | 2.3 | 10.8 | 40.2 | 37 | 21 | 21 | 3 | 10 | 48 | 0 | 0 | 0 | 0 | 3 | 1 | 0 | 2.40 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 6 | 6 | 2 | 3 | 3.79 | .271 | 1.09 | 7.7 | 2.3 | 9.9 | 40.1 | 34 | 20 | 17 | 1 | 10 | 44 | 2 | 0 | 0 | 1 | 5 | 1 | 3 | 1.95 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 76 | 6 | 6 | 5 | 0 | 3.79 | .296 | 1.24 | 6.6 | 4.5 | 7.3 | 38.0 | 28 | 16 | 16 | 3 | 19 | 31 | 0 | 0 | 0 | 0 | 3 | 1 | 2 | 3.97 |
| SP | Bender, C.Bender, Chief # >> | 26 | 1910 | R | 72 | 5 | 5 | 0 | 2 | 4.97 | .352 | 1.58 | 10.4 | 3.8 | 5.0 | 38.0 | 44 | 25 | 21 | 3 | 16 | 21 | 0 | 0 | 0 | 0 | 2 | 2 | 1 | 4.34 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 14 | 0 | 2 | 2 | 3.26 | .284 | 1.19 | 8.1 | 2.8 | 9.0 | 19.1 | 17 | 7 | 7 | 2 | 6 | 19 | 0 | 2 | 2 | 0 | 0 | 0 | 0 | 3.32 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 71 | 15 | 0 | 0 | 0 | 1.88 | .295 | 1.12 | 6.4 | 3.9 | 6.4 | 14.1 | 10 | 5 | 3 | 0 | 6 | 10 | 0 | 5 | 0 | 0 | 0 | 2 | 0 | 3.29 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 64 | 4 | 0 | 0 | 1 | 30.00 | .625 | 4.67 | 27.0 | 15.0 | 6.0 | 3.0 | 9 | 11 | 10 | 1 | 5 | 2 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 12.00 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 58 | 1 | 0 | 0 | 0 | 0.00 | .000 | 0.00 | - | - | - | 0.1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |