| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 25 | 25 | 9 | 6 | 3.56 | .289 | 1.17 | 7.7 | 2.8 | 8.6 | 167.0 | 143 | 73 | 66 | 18 | 52 | 160 | 0 | 0 | 0 | 0 | 18 | 9 | 0 | 3.58 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 24 | 24 | 8 | 8 | 5.06 | .326 | 1.43 | 9.3 | 3.5 | 7.2 | 162.0 | 168 | 92 | 91 | 23 | 63 | 129 | 0 | 0 | 0 | 0 | 10 | 4 | 2 | 4.49 |
| SP | Coveleski, S.Coveleski, Stan >> | 28 | 1917 | R | 62 | 23 | 23 | 7 | 8 | 4.80 | .352 | 1.61 | 9.5 | 5.1 | 5.6 | 144.1 | 152 | 90 | 77 | 15 | 81 | 90 | 1 | 0 | 0 | 0 | 10 | 2 | 0 | 4.83 |
| RP | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 67 | 0 | 6 | 4 | 3.77 | .303 | 1.27 | 8.4 | 3.0 | 8.1 | 98.0 | 91 | 46 | 41 | 15 | 33 | 88 | 0 | 8 | 6 | 0 | 0 | 4 | 2 | 4.33 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 57 | 0 | 4 | 5 | 3.25 | .307 | 1.33 | 9.4 | 2.7 | 8.9 | 74.2 | 77 | 34 | 27 | 7 | 22 | 73 | 0 | 8 | 2 | 0 | 0 | 0 | 0 | 3.15 |
| RP | Williams, D.Williams, Devin # >> | 28 | 2023 | R | 72 | 45 | 0 | 2 | 7 | 5.92 | .348 | 1.56 | 7.7 | 6.6 | 9.4 | 48.2 | 41 | 34 | 32 | 3 | 35 | 50 | 0 | 7 | 1 | 0 | 0 | 2 | 1 | 4.04 |
| RP | Broxton, J.Broxton, Jonathan >> | 25 | 2009 | R | 62 | 36 | 0 | 2 | 0 | 4.20 | .304 | 1.31 | 7.6 | 4.2 | 9.0 | 45.0 | 38 | 24 | 21 | 7 | 21 | 45 | 0 | 3 | 2 | 0 | 0 | 0 | 1 | 4.42 |
| SP | Hudson, D.Hudson, Daniel >> | 23 | 2010 | R | 60 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Tanana, F.Tanana, Frank >> | 23 | 1976 | L | 58 | 3 | 0 | 0 | 0 | 0.00 | .222 | 0.86 | 9.0 | 0.0 | 4.5 | 2.1 | 2 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.00 |
| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 56 | 25 | 0 | 2 | 5 | 9.00 | .400 | 1.94 | 13.6 | 3.8 | 4.4 | 33.0 | 50 | 35 | 33 | 8 | 14 | 16 | 0 | 1 | 0 | 0 | 0 | 2 | 1 | 6.64 |