| SP | Leonard, D.Leonard, Dutch >> | 22 | 1914 | L | 91 | 33 | 33 | 14 | 9 | 3.67 | .289 | 1.20 | 7.5 | 3.4 | 4.9 | 213.1 | 177 | 89 | 87 | 18 | 80 | 115 | 1 | 0 | 0 | 0 | 21 | 3 | 2 | 4.19 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 33 | 32 | 13 | 8 | 3.92 | .297 | 1.26 | 8.1 | 3.3 | 8.5 | 202.0 | 181 | 100 | 88 | 31 | 73 | 191 | 1 | 0 | 0 | 0 | 19 | 2 | 3 | 4.22 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 84 | 0 | 8 | 1 | 3.26 | .292 | 1.23 | 6.0 | 5.1 | 8.8 | 99.1 | 66 | 38 | 36 | 13 | 56 | 97 | 0 | 3 | 3 | 0 | 0 | 1 | 0 | 4.47 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 80 | 63 | 0 | 6 | 5 | 3.50 | .300 | 1.24 | 7.0 | 4.2 | 10.3 | 69.1 | 54 | 29 | 27 | 5 | 32 | 79 | 0 | 2 | 2 | 0 | 0 | 3 | 0 | 3.17 |
| RP | Bautista, F.Bautista, Félix # >> | 28 | 2023 | R | 75 | 46 | 0 | 4 | 3 | 4.74 | .330 | 1.46 | 8.4 | 4.8 | 11.6 | 49.1 | 46 | 26 | 26 | 4 | 26 | 63 | 0 | 0 | 3 | 0 | 0 | 1 | 4 | 3.14 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 71 | 38 | 0 | 2 | 2 | 3.72 | .320 | 1.39 | 5.7 | 6.8 | 8.6 | 46.0 | 29 | 19 | 19 | 3 | 35 | 44 | 0 | 1 | 1 | 0 | 0 | 1 | 2 | 4.28 |
| SP | McDowell, S.McDowell, Sam † # >> | 23 | 1965 | L | 44 | 33 | 31 | 17 | 6 | 3.21 | .303 | 1.29 | 7.2 | 4.4 | 8.0 | 199.0 | 160 | 76 | 71 | 11 | 97 | 176 | 1 | 0 | 0 | 0 | 19 | 3 | 12 | 3.46 |
| CL | Gagne, E.Gagne, Eric † >> | 27 | 2003 | R | 98 | 78 | 0 | 3 | 4 | 2.48 | .291 | 1.21 | 8.0 | 2.9 | 7.9 | 87.0 | 77 | 24 | 24 | 7 | 28 | 76 | 0 | 45 | 5 | 0 | 0 | 2 | 3 | 3.33 |