| SP | Koufax, S.Koufax, Sandy † >> | 30 | 1965 | L | 97 | 32 | 32 | 17 | 9 | 3.15 | .281 | 1.16 | 7.4 | 3.0 | 8.7 | 243.0 | 199 | 90 | 85 | 23 | 82 | 236 | 5 | 0 | 0 | 0 | 23 | 4 | 2 | 3.35 |
| SP | Alexander, P.Alexander, Pete >> | 28 | 1915 | R | 88 | 32 | 32 | 9 | 16 | 4.24 | .289 | 1.20 | 8.1 | 2.7 | 4.8 | 222.2 | 201 | 109 | 105 | 20 | 66 | 118 | 6 | 0 | 0 | 0 | 17 | 4 | 4 | 4.05 |
| SP | Mathewson, C.Mathewson, Christy >> | 28 | 1908 | R | 83 | 32 | 32 | 10 | 14 | 3.84 | .297 | 1.23 | 8.6 | 2.5 | 4.8 | 225.0 | 214 | 100 | 96 | 20 | 62 | 121 | 4 | 0 | 0 | 1 | 19 | 9 | 3 | 4.03 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 76 | 31 | 31 | 8 | 12 | 4.25 | .320 | 1.38 | 8.2 | 4.3 | 7.1 | 184.1 | 167 | 94 | 87 | 26 | 87 | 146 | 0 | 0 | 0 | 0 | 17 | 6 | 1 | 4.77 |
| CL | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 51 | 0 | 3 | 10 | 3.97 | .269 | 1.08 | 7.5 | 2.3 | 9.0 | 59.0 | 49 | 26 | 26 | 6 | 15 | 59 | 0 | 23 | 4 | 0 | 0 | 1 | 0 | 3.14 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 61 | 0 | 0 | 3 | 5.05 | .280 | 1.15 | 7.0 | 3.4 | 10.4 | 66.0 | 51 | 37 | 37 | 13 | 25 | 76 | 0 | 6 | 5 | 0 | 0 | 1 | 0 | 4.44 |
| RP | Gossage, R.Gossage, Rich >> | 30 | 1981 | R | 90 | 81 | 0 | 3 | 3 | 3.35 | .259 | 1.04 | 6.2 | 3.1 | 9.2 | 78.0 | 54 | 30 | 29 | 13 | 27 | 80 | 0 | 3 | 1 | 0 | 0 | 1 | 0 | 4.19 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 53 | 0 | 2 | 5 | 5.56 | .352 | 1.61 | 11.4 | 3.2 | 9.4 | 45.1 | 57 | 30 | 28 | 11 | 16 | 47 | 0 | 1 | 2 | 0 | 0 | 1 | 1 | 5.22 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 85 | 35 | 0 | 2 | 0 | 2.62 | .248 | 0.96 | 6.6 | 2.1 | 10.3 | 34.1 | 25 | 10 | 10 | 4 | 8 | 39 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 3.03 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 73 | 0 | 3 | 3 | 4.77 | .322 | 1.41 | 8.8 | 4.0 | 7.3 | 54.2 | 53 | 31 | 29 | 9 | 24 | 44 | 0 | 0 | 4 | 0 | 0 | 1 | 7 | 4.93 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 75 | 32 | 0 | 2 | 2 | 4.89 | .323 | 1.43 | 8.7 | 4.1 | 9.3 | 35.0 | 34 | 19 | 19 | 6 | 16 | 36 | 0 | 0 | 1 | 0 | 0 | 0 | 4 | 4.54 |