| SP | Martinez, P.Martinez, Pedro >> | 29 | 2000 | R | 100 | 28 | 28 | 8 | 13 | 4.76 | .304 | 1.30 | 9.0 | 2.7 | 8.2 | 151.1 | 151 | 81 | 80 | 10 | 45 | 138 | 5 | 0 | 0 | 2 | 13 | 2 | 3 | 2.97 |
| SP | Cueto, J.Cueto, Johnny >> | 28 | 2014 | R | 75 | 28 | 28 | 7 | 8 | 5.21 | .319 | 1.38 | 8.8 | 3.7 | 5.5 | 133.0 | 130 | 84 | 77 | 19 | 54 | 81 | 1 | 0 | 0 | 1 | 10 | 3 | 2 | 4.92 |
| RP | Chapman, A.Chapman, Aroldis >> | 26 | 2014 | L | 94 | 84 | 0 | 8 | 0 | 4.57 | .310 | 1.32 | 7.5 | 4.5 | 11.4 | 84.2 | 70 | 45 | 43 | 6 | 42 | 106 | 0 | 3 | 1 | 0 | 0 | 2 | 3 | 2.98 |
| CL | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 68 | 0 | 6 | 3 | 3.63 | .310 | 1.35 | 8.1 | 4.1 | 10.1 | 79.1 | 71 | 34 | 32 | 10 | 36 | 89 | 0 | 22 | 4 | 0 | 0 | 0 | 0 | 3.76 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 82 | 0 | 3 | 2 | 4.15 | .309 | 1.29 | 9.1 | 2.5 | 8.2 | 93.1 | 94 | 45 | 43 | 10 | 26 | 85 | 0 | 1 | 2 | 0 | 0 | 5 | 2 | 3.57 |
| SU | Devine, J.Devine, Joey >> | 25 | 2008 | R | 80 | 75 | 0 | 3 | 6 | 4.97 | .320 | 1.38 | 7.3 | 5.2 | 8.7 | 88.2 | 71 | 49 | 49 | 7 | 51 | 85 | 0 | 1 | 7 | 0 | 0 | 3 | 0 | 3.94 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 73 | 71 | 0 | 9 | 4 | 4.50 | .306 | 1.31 | 8.4 | 3.5 | 8.4 | 86.0 | 80 | 47 | 43 | 13 | 33 | 80 | 0 | 1 | 2 | 0 | 0 | 1 | 0 | 4.29 |