| SP | Tiant, L.Tiant, Luis # >> | 28 | 1968 | R | 97 | 34 | 34 | 9 | 17 | 5.49 | .328 | 1.43 | 9.3 | 3.7 | 7.7 | 214.2 | 220 | 133 | 131 | 38 | 87 | 183 | 6 | 0 | 0 | 1 | 16 | 7 | 5 | 4.92 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 33 | 33 | 11 | 12 | 4.10 | .310 | 1.33 | 9.2 | 2.8 | 9.3 | 197.2 | 201 | 100 | 90 | 29 | 61 | 203 | 0 | 0 | 0 | 0 | 18 | 4 | 3 | 3.84 |
| SP | Hendrix, C.Hendrix, Claude >> | 25 | 1914 | R | 69 | 32 | 32 | 6 | 18 | 6.33 | .359 | 1.66 | 11.1 | 3.8 | 4.5 | 192.0 | 236 | 142 | 135 | 26 | 82 | 95 | 3 | 0 | 0 | 0 | 8 | 5 | 7 | 5.13 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 83 | 0 | 6 | 5 | 3.93 | .338 | 1.50 | 8.3 | 5.3 | 7.6 | 112.1 | 103 | 50 | 49 | 11 | 66 | 95 | 0 | 3 | 2 | 0 | 0 | 3 | 3 | 4.43 |
| RP | Soria, J.Soria, Joakim # >> | 24 | 2008 | R | 68 | 84 | 0 | 5 | 3 | 5.00 | .310 | 1.34 | 8.5 | 3.6 | 7.5 | 113.1 | 107 | 66 | 63 | 19 | 45 | 94 | 0 | 9 | 4 | 0 | 0 | 1 | 1 | 4.74 |
| RP | Urbina, U.Urbina, Ugueth >> | 24 | 1998 | R | 59 | 68 | 0 | 2 | 8 | 3.51 | .285 | 1.18 | 5.7 | 4.9 | 9.3 | 82.0 | 52 | 36 | 32 | 10 | 45 | 85 | 0 | 9 | 2 | 0 | 0 | 1 | 2 | 4.20 |
| SP | Reulbach, E.Reulbach, Ed >> | 24 | 1906 | R | 60 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Saberhagen, B.Saberhagen, Bret >> | 25 | 1989 | R | 51 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Caldwell, R.Caldwell, Ray >> | 26 | 1914 | R | 64 | 3 | 0 | 0 | 0 | 5.40 | .250 | 0.80 | 5.4 | 1.8 | 9.0 | 5.0 | 3 | 3 | 3 | 1 | 1 | 5 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.80 |
| SP | Drysdale, D.Drysdale, Don >> | 28 | 1964 | R | 59 | 41 | 0 | 3 | 6 | 6.42 | .371 | 1.73 | 12.0 | 3.7 | 5.4 | 75.2 | 100 | 64 | 54 | 15 | 31 | 45 | 0 | 3 | 2 | 0 | 0 | 3 | 3 | 5.76 |