| SP | Koufax, S.Koufax, Sandy $ >> | 30 | 1965 | L | 97 | 21 | 21 | 9 | 7 | 5.27 | .346 | 1.56 | 11.1 | 3.0 | 8.3 | 124.2 | 153 | 74 | 73 | 19 | 42 | 115 | 1 | 0 | 0 | 0 | 8 | 3 | 2 | 4.23 |
| SP | Gibson, B.Gibson, Bob # >> | 33 | 1968 | R | 92 | 20 | 20 | 8 | 6 | 4.72 | .303 | 1.28 | 8.8 | 2.8 | 5.9 | 131.2 | 128 | 72 | 69 | 15 | 41 | 86 | 5 | 0 | 0 | 0 | 11 | 3 | 4 | 4.18 |
| SP | Snell, B.Snell, Blake # >> | 25 | 2018 | L | 80 | 19 | 19 | 4 | 10 | 4.65 | .327 | 1.43 | 8.3 | 4.7 | 10.4 | 98.2 | 90 | 62 | 51 | 6 | 51 | 113 | 0 | 0 | 0 | 0 | 8 | 3 | 2 | 3.14 |
| SP | Guidry, R.Guidry, Ron # >> | 28 | 1978 | L | 77 | 19 | 19 | 6 | 10 | 4.71 | .326 | 1.43 | 9.5 | 3.4 | 6.2 | 120.1 | 127 | 71 | 63 | 13 | 45 | 83 | 3 | 0 | 0 | 0 | 9 | 3 | 3 | 4.23 |
| SP | Bender, C.Bender, Chief # >> | 26 | 1910 | R | 71 | 19 | 19 | 3 | 6 | 6.56 | .341 | 1.53 | 10.5 | 3.4 | 4.4 | 93.1 | 108 | 70 | 68 | 13 | 35 | 45 | 1 | 0 | 0 | 0 | 6 | 2 | 4 | 5.04 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 67 | 49 | 0 | 1 | 1 | 4.62 | .322 | 1.41 | 8.3 | 4.5 | 6.2 | 60.1 | 55 | 34 | 31 | 2 | 30 | 41 | 0 | 2 | 1 | 0 | 0 | 1 | 3 | 3.62 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 77 | 47 | 0 | 5 | 3 | 4.69 | .316 | 1.31 | 9.8 | 2.1 | 7.5 | 55.2 | 60 | 30 | 29 | 9 | 13 | 46 | 0 | 1 | 2 | 0 | 0 | 4 | 0 | 4.38 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 84 | 37 | 0 | 4 | 1 | 3.42 | .264 | 1.04 | 7.1 | 2.3 | 7.5 | 47.1 | 37 | 18 | 18 | 4 | 12 | 39 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 3.34 |
| CL | Kimbrel, C.Kimbrel, Craig >> | 24 | 2012 | R | 100 | 37 | 0 | 2 | 3 | 2.63 | .289 | 1.19 | 7.3 | 3.6 | 10.0 | 37.2 | 30 | 13 | 11 | 4 | 15 | 41 | 0 | 19 | 5 | 0 | 0 | 1 | 3 | 3.49 |
| SP | Newhouser, H.Newhouser, Hal >> | 25 | 1946 | L | 30 | 20 | 0 | 0 | 4 | 4.71 | .341 | 1.56 | 9.9 | 4.1 | 5.6 | 63.0 | 69 | 35 | 33 | 4 | 29 | 39 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 3.97 |