| SP | Hernandez, F.Hernandez, Felix >> | 28 | 2014 | R | 79 | 28 | 28 | 7 | 14 | 5.84 | .342 | 1.53 | 10.5 | 3.4 | 8.0 | 152.2 | 177 | 102 | 99 | 25 | 57 | 135 | 2 | 0 | 0 | 0 | 11 | 4 | 6 | 4.57 |
| SP | Clemens, R.Clemens, Roger # >> | 24 | 1986 | R | 69 | 27 | 27 | 10 | 10 | 4.59 | .313 | 1.35 | 8.9 | 3.3 | 5.6 | 170.2 | 168 | 102 | 87 | 23 | 63 | 105 | 5 | 0 | 0 | 1 | 12 | 2 | 5 | 4.67 |
| SP | Chesbro, J.Chesbro, Jack >> | 30 | 1904 | R | 65 | 27 | 27 | 9 | 10 | 4.55 | .323 | 1.42 | 9.8 | 3.0 | 3.9 | 182.0 | 198 | 97 | 92 | 21 | 60 | 79 | 7 | 0 | 0 | 2 | 10 | 3 | 4 | 4.67 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 86 | 0 | 2 | 3 | 2.90 | .228 | 0.86 | 5.5 | 2.3 | 8.3 | 77.2 | 47 | 28 | 25 | 7 | 20 | 71 | 0 | 7 | 1 | 0 | 0 | 2 | 1 | 3.19 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 74 | 0 | 4 | 3 | 3.72 | .318 | 1.38 | 8.4 | 4.1 | 9.0 | 77.1 | 72 | 35 | 32 | 11 | 35 | 77 | 0 | 5 | 2 | 0 | 0 | 1 | 1 | 4.26 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 57 | 47 | 0 | 5 | 6 | 4.87 | .330 | 1.43 | 8.1 | 4.9 | 5.1 | 88.2 | 79 | 54 | 48 | 5 | 48 | 50 | 0 | 3 | 0 | 0 | 0 | 4 | 2 | 4.38 |
| SP | Saberhagen, B.Saberhagen, Bret >> | 25 | 1989 | R | 50 | 1 | 0 | 0 | 0 | 18.00 | .455 | 2.50 | 18.0 | 4.5 | 4.5 | 2.0 | 4 | 4 | 4 | 2 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 16.50 |
| SP | Tanana, F.Tanana, Frank >> | 23 | 1976 | L | 57 | 8 | 0 | 0 | 2 | 5.40 | .348 | 1.60 | 10.2 | 4.2 | 6.0 | 15.0 | 17 | 12 | 9 | 2 | 7 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 4.80 |
| SP | Hudson, D.Hudson, Daniel >> | 23 | 2010 | R | 59 | 31 | 0 | 3 | 3 | 4.60 | .320 | 1.41 | 9.0 | 3.9 | 6.8 | 58.2 | 58 | 30 | 30 | 8 | 25 | 44 | 0 | 2 | 0 | 0 | 0 | 0 | 3 | 4.57 |