| SP | Adams, B.Adams, Babe # >> | 27 | 1909 | R | 86 | 20 | 20 | 6 | 7 | 3.45 | .296 | 1.24 | 7.9 | 3.3 | 4.7 | 109.2 | 96 | 47 | 42 | 9 | 40 | 57 | 0 | 0 | 0 | 0 | 7 | 2 | 2 | 4.18 |
| SP | Pfiester, J.Pfiester, Jack † >> | 28 | 1906 | L | 74 | 20 | 20 | 11 | 6 | 3.47 | .293 | 1.21 | 7.8 | 3.0 | 4.9 | 163.1 | 142 | 67 | 63 | 17 | 55 | 89 | 8 | 0 | 0 | 1 | 13 | 6 | 4 | 4.39 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 73 | 19 | 19 | 9 | 6 | 4.86 | .340 | 1.54 | 11.4 | 2.4 | 4.3 | 133.1 | 169 | 80 | 72 | 13 | 36 | 64 | 2 | 0 | 0 | 1 | 8 | 1 | 2 | 4.14 |
| SP | Caldwell, R.Caldwell, Ray >> | 26 | 1914 | R | 63 | 19 | 19 | 5 | 5 | 6.13 | .337 | 1.53 | 10.9 | 2.9 | 4.2 | 116.0 | 140 | 82 | 79 | 28 | 37 | 54 | 0 | 0 | 0 | 0 | 7 | 0 | 1 | 6.16 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 55 | 0 | 5 | 6 | 3.91 | .265 | 1.05 | 6.8 | 2.7 | 7.8 | 76.0 | 57 | 34 | 33 | 14 | 23 | 66 | 0 | 7 | 4 | 0 | 0 | 2 | 2 | 4.64 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 47 | 0 | 1 | 4 | 3.12 | .286 | 1.17 | 8.9 | 1.8 | 6.9 | 60.2 | 59 | 21 | 21 | 4 | 12 | 46 | 0 | 8 | 3 | 0 | 0 | 2 | 0 | 3.03 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 72 | 34 | 0 | 1 | 2 | 2.92 | .288 | 1.22 | 5.8 | 5.1 | 7.8 | 37.0 | 24 | 12 | 12 | 4 | 21 | 32 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 4.38 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 63 | 20 | 0 | 0 | 1 | 2.78 | .352 | 1.63 | 6.1 | 9.0 | 9.4 | 22.2 | 15 | 9 | 7 | 1 | 22 | 23 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 4.50 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 60 | 8 | 0 | 2 | 0 | 3.77 | .348 | 1.53 | 7.1 | 7.1 | 5.8 | 14.1 | 11 | 6 | 6 | 0 | 11 | 9 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 4.29 |