| SP | Martinez, P.Martinez, Pedro # $ >> | 29 | 2000 | R | 100 | 38 | 38 | 19 | 10 | 3.05 | .272 | 1.10 | 7.7 | 2.3 | 8.4 | 268.1 | 228 | 98 | 91 | 38 | 67 | 249 | 9 | 0 | 0 | 2 | 26 | 6 | 4 | 3.80 |
| SP | Arrieta, J.Arrieta, Jake # >> | 29 | 2015 | R | 92 | 36 | 36 | 6 | 20 | 7.08 | .383 | 1.82 | 12.1 | 4.3 | 8.5 | 175.1 | 235 | 142 | 138 | 37 | 84 | 165 | 0 | 0 | 0 | 0 | 9 | 7 | 7 | 5.42 |
| SP | Guidry, R.Guidry, Ron # >> | 28 | 1978 | L | 78 | 34 | 34 | 12 | 7 | 6.04 | .351 | 1.59 | 10.8 | 3.6 | 6.4 | 187.2 | 225 | 128 | 126 | 20 | 74 | 134 | 4 | 0 | 0 | 0 | 11 | 5 | 4 | 4.22 |
| CL | Adams, M.Adams, Mike † >> | 31 | 2009 | R | 99 | 86 | 0 | 8 | 6 | 3.33 | .296 | 1.24 | 6.6 | 4.6 | 9.2 | 108.0 | 79 | 40 | 40 | 10 | 55 | 110 | 0 | 24 | 5 | 0 | 0 | 2 | 0 | 3.75 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 100 | 0 | 5 | 3 | 4.84 | .320 | 1.37 | 8.3 | 4.1 | 9.7 | 109.2 | 100 | 66 | 59 | 21 | 50 | 117 | 0 | 6 | 9 | 0 | 0 | 5 | 0 | 4.87 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 92 | 103 | 0 | 5 | 4 | 3.54 | .308 | 1.31 | 8.8 | 3.0 | 8.0 | 122.0 | 119 | 58 | 48 | 20 | 41 | 109 | 0 | 3 | 3 | 0 | 0 | 3 | 0 | 4.43 |
| RP | Clippard, T.Clippard, Tyler † >> | 26 | 2011 | R | 79 | 78 | 0 | 15 | 2 | 4.15 | .316 | 1.35 | 8.0 | 4.2 | 8.4 | 112.2 | 100 | 54 | 52 | 10 | 52 | 105 | 0 | 2 | 0 | 0 | 0 | 4 | 0 | 3.79 |