| SP | deGrom, J.deGrom, Jacob $ >> | 33 | 2021 | R | 100 | 19 | 19 | 8 | 6 | 3.06 | .273 | 1.09 | 7.0 | 2.9 | 10.9 | 123.1 | 96 | 49 | 42 | 16 | 39 | 149 | 1 | 0 | 0 | 0 | 13 | 4 | 0 | 3.32 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 87 | 19 | 18 | 9 | 6 | 4.36 | .286 | 1.17 | 7.9 | 2.7 | 6.3 | 95.0 | 83 | 51 | 46 | 15 | 28 | 66 | 0 | 0 | 0 | 0 | 8 | 3 | 1 | 4.64 |
| SP | Hunter, C.Hunter, Catfish >> | 26 | 1972 | R | 85 | 18 | 17 | 7 | 5 | 4.61 | .323 | 1.40 | 9.5 | 3.1 | 6.3 | 121.0 | 128 | 68 | 62 | 26 | 42 | 85 | 3 | 0 | 0 | 0 | 8 | 3 | 0 | 5.50 |
| SP | Perez, O.Perez, Odalis # >> | 25 | 2002 | L | 52 | 18 | 18 | 10 | 1 | 4.09 | .331 | 1.45 | 9.8 | 3.3 | 6.4 | 112.1 | 122 | 63 | 51 | 10 | 41 | 80 | 0 | 0 | 0 | 0 | 10 | 4 | 4 | 3.94 |
| RP | Jackson, M.Jackson, Mike >> | 30 | 1994 | R | 82 | 51 | 0 | 5 | 1 | 3.56 | .271 | 1.10 | 7.0 | 2.9 | 9.5 | 55.2 | 43 | 23 | 22 | 8 | 18 | 58 | 0 | 2 | 1 | 0 | 0 | 1 | 0 | 3.82 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 68 | 22 | 0 | 3 | 1 | 4.05 | .286 | 1.05 | 5.9 | 3.6 | 11.3 | 20.0 | 13 | 9 | 9 | 3 | 8 | 25 | 0 | 1 | 3 | 0 | 0 | 3 | 3 | 4.10 |
| SU | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 74 | 31 | 0 | 0 | 0 | 2.50 | .239 | 0.94 | 5.8 | 2.8 | 10.0 | 36.0 | 23 | 11 | 10 | 4 | 11 | 40 | 0 | 1 | 4 | 0 | 0 | 0 | 0 | 3.14 |
| CL | Uehara, K.Uehara, Koji † >> | 38 | 2013 | R | 100 | 35 | 0 | 3 | 3 | 3.90 | .322 | 1.42 | 9.8 | 3.1 | 8.7 | 32.1 | 35 | 14 | 14 | 6 | 11 | 31 | 0 | 24 | 5 | 0 | 0 | 0 | 0 | 4.53 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 74 | 29 | 0 | 1 | 0 | 3.00 | .280 | 1.17 | 9.3 | 1.2 | 8.4 | 30.0 | 31 | 13 | 10 | 2 | 4 | 28 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 2.40 |
| SP | Flaherty, J.Flaherty, Jack >> | 23 | 2019 | R | 82 | 16 | 11 | 3 | 4 | 4.17 | .332 | 1.49 | 10.3 | 3.3 | 9.5 | 77.2 | 88 | 36 | 36 | 7 | 28 | 81 | 0 | 0 | 0 | 0 | 5 | 0 | 2 | 3.17 |