| SP | Johnson, R.Johnson, Randy # >> | 38 | 2001 | L | 74 | 33 | 33 | 12 | 15 | 4.52 | .314 | 1.33 | 9.0 | 3.0 | 10.4 | 221.0 | 221 | 122 | 111 | 32 | 73 | 256 | 4 | 0 | 0 | 2 | 16 | 10 | 1 | 3.69 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 75 | 32 | 32 | 8 | 13 | 5.50 | .332 | 1.45 | 9.8 | 3.3 | 9.0 | 168.2 | 183 | 108 | 103 | 28 | 61 | 168 | 0 | 0 | 0 | 0 | 7 | 7 | 10 | 4.38 |
| SP | Saberhagen, B.Saberhagen, Bret >> | 25 | 1989 | R | 64 | 31 | 31 | 10 | 19 | 5.37 | .337 | 1.50 | 10.7 | 2.8 | 6.1 | 197.2 | 234 | 122 | 118 | 30 | 62 | 134 | 3 | 0 | 0 | 1 | 15 | 6 | 4 | 4.65 |
| RP | Edwards, C.Edwards, Carl >> | 24 | 2016 | R | 93 | 78 | 0 | 3 | 2 | 2.76 | .281 | 1.16 | 5.3 | 5.1 | 9.3 | 98.0 | 58 | 32 | 30 | 10 | 56 | 101 | 0 | 2 | 3 | 0 | 0 | 1 | 11 | 4.01 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 82 | 66 | 0 | 3 | 3 | 4.41 | .307 | 1.28 | 7.2 | 4.4 | 10.4 | 69.1 | 55 | 35 | 34 | 8 | 34 | 80 | 0 | 1 | 1 | 0 | 0 | 3 | 2 | 3.80 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 77 | 49 | 0 | 4 | 4 | 4.36 | .318 | 1.36 | 8.0 | 4.4 | 9.5 | 53.2 | 47 | 27 | 26 | 6 | 26 | 56 | 0 | 2 | 2 | 0 | 0 | 2 | 0 | 3.94 |
| CL | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 86 | 59 | 0 | 1 | 1 | 3.15 | .315 | 1.36 | 9.2 | 3.2 | 9.2 | 54.1 | 55 | 21 | 19 | 2 | 19 | 55 | 0 | 41 | 6 | 0 | 0 | 1 | 0 | 2.56 |
| SP | DeLeon, J.DeLeon, Jose >> | 29 | 1989 | R | 59 | 25 | 0 | 4 | 0 | 4.78 | .328 | 1.43 | 8.0 | 4.9 | 7.3 | 107.1 | 95 | 60 | 57 | 18 | 58 | 87 | 0 | 0 | 0 | 0 | 0 | 4 | 2 | 5.30 |