| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 95 | 34 | 34 | 9 | 19 | 5.12 | .319 | 1.38 | 8.8 | 3.6 | 8.3 | 218.0 | 214 | 129 | 124 | 35 | 86 | 202 | 4 | 0 | 0 | 1 | 16 | 6 | 7 | 4.50 |
| SP | Hudson, D.Hudson, Daniel >> | 23 | 2010 | R | 71 | 33 | 33 | 8 | 13 | 5.29 | .347 | 1.57 | 9.9 | 4.2 | 6.5 | 197.1 | 217 | 128 | 116 | 34 | 92 | 142 | 1 | 0 | 0 | 0 | 13 | 6 | 7 | 5.29 |
| SP | Brown, K.Brown, Kevin # >> | 31 | 1996 | R | 67 | 32 | 32 | 10 | 16 | 4.17 | .304 | 1.26 | 9.2 | 2.2 | 6.1 | 230.2 | 235 | 110 | 107 | 34 | 56 | 156 | 8 | 0 | 0 | 1 | 19 | 11 | 6 | 4.44 |
| SP | Darvish, Y.Darvish, Yu >> | 26 | 2013 | R | 55 | 31 | 31 | 5 | 15 | 6.41 | .358 | 1.65 | 9.5 | 5.3 | 9.7 | 171.1 | 181 | 126 | 122 | 32 | 101 | 185 | 1 | 0 | 0 | 0 | 10 | 5 | 1 | 5.13 |
| RP | Benoit, J.Benoit, Joaquin >> | 33 | 2010 | R | 94 | 88 | 0 | 2 | 3 | 3.92 | .308 | 1.31 | 7.7 | 4.1 | 9.5 | 108.0 | 92 | 50 | 47 | 15 | 49 | 114 | 0 | 10 | 6 | 0 | 0 | 3 | 3 | 4.14 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 72 | 73 | 0 | 3 | 3 | 3.48 | .294 | 1.20 | 6.1 | 4.7 | 9.8 | 93.0 | 63 | 36 | 36 | 10 | 49 | 101 | 0 | 4 | 1 | 0 | 0 | 4 | 1 | 3.94 |
| RP | Wuertz, M.Wuertz, Michael >> | 31 | 2009 | R | 48 | 54 | 0 | 3 | 6 | 4.75 | .360 | 1.65 | 9.3 | 5.6 | 11.3 | 55.0 | 57 | 31 | 29 | 9 | 34 | 69 | 0 | 2 | 4 | 0 | 0 | 2 | 4 | 4.58 |
| RP | Rincon, J.Rincon, Juan >> | 25 | 2004 | R | 40 | 51 | 0 | 2 | 5 | 5.31 | .324 | 1.42 | 8.5 | 4.4 | 10.4 | 57.2 | 54 | 34 | 34 | 12 | 28 | 66 | 0 | 2 | 2 | 0 | 0 | 1 | 1 | 4.95 |
| SP | Krukow, M.Krukow, Mike >> | 34 | 1986 | R | 34 | 3 | 0 | 0 | 0 | 15.00 | .419 | 2.17 | 15.0 | 4.5 | 9.0 | 6.0 | 10 | 10 | 10 | 2 | 3 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6.83 |