| SP | Martinez, P.Martinez, Pedro † >> | 29 | 2000 | R | 100 | 32 | 32 | 15 | 8 | 2.89 | .275 | 1.11 | 7.0 | 3.0 | 8.3 | 252.2 | 196 | 92 | 81 | 17 | 84 | 232 | 6 | 0 | 0 | 1 | 21 | 7 | 3 | 3.12 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 92 | 31 | 31 | 7 | 19 | 4.97 | .341 | 1.53 | 9.6 | 4.1 | 8.3 | 211.2 | 226 | 125 | 117 | 23 | 97 | 195 | 3 | 0 | 0 | 1 | 14 | 5 | 5 | 4.02 |
| SP | Mathewson, C.Mathewson, Christy >> | 28 | 1908 | R | 83 | 31 | 31 | 16 | 9 | 4.10 | .287 | 1.16 | 8.2 | 2.3 | 5.5 | 230.2 | 209 | 111 | 105 | 24 | 58 | 140 | 6 | 0 | 0 | 1 | 15 | 11 | 4 | 4.04 |
| SP | Reulbach, E.Reulbach, Ed >> | 24 | 1906 | R | 60 | 30 | 30 | 16 | 9 | 3.66 | .305 | 1.28 | 7.4 | 4.2 | 3.2 | 216.2 | 177 | 96 | 88 | 19 | 100 | 77 | 5 | 0 | 0 | 1 | 19 | 8 | 1 | 4.93 |
| SP | McLain, D.McLain, Denny † # >> | 24 | 1968 | R | 79 | 29 | 29 | 16 | 10 | 3.54 | .287 | 1.18 | 8.1 | 2.5 | 5.0 | 244.1 | 220 | 104 | 96 | 21 | 69 | 136 | 18 | 0 | 0 | 4 | 15 | 6 | 3 | 3.93 |
| RP | Hader, J.Hader, Josh # $ >> | 24 | 2018 | L | 93 | 86 | 0 | 3 | 2 | 4.66 | .306 | 1.30 | 7.9 | 3.9 | 8.7 | 56.0 | 49 | 30 | 29 | 6 | 24 | 54 | 0 | 7 | 5 | 0 | 0 | 1 | 0 | 3.80 |
| RP | Jansen, K.Jansen, Kenley $ >> | 28 | 2016 | R | 97 | 67 | 0 | 4 | 4 | 2.61 | .235 | 0.89 | 6.0 | 2.0 | 9.0 | 62.0 | 41 | 22 | 18 | 6 | 14 | 62 | 0 | 6 | 3 | 0 | 0 | 2 | 1 | 3.03 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 76 | 14 | 0 | 2 | 0 | 2.63 | .268 | 1.10 | 6.2 | 4.2 | 10.4 | 13.2 | 9 | 4 | 4 | 1 | 6 | 15 | 0 | 3 | 1 | 0 | 0 | 0 | 0 | 3.08 |
| RP | Broxton, J.Broxton, Jonathan >> | 25 | 2009 | R | 63 | 9 | 0 | 0 | 2 | 2.16 | .286 | 1.20 | 7.9 | 3.4 | 9.0 | 8.1 | 7 | 4 | 2 | 1 | 3 | 8 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 3.75 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 73 | 13 | 0 | 0 | 0 | 3.78 | .219 | 0.84 | 5.6 | 2.3 | 8.4 | 16.2 | 10 | 8 | 7 | 6 | 4 | 15 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 6.75 |
| SP | Schilling, C.Schilling, Curt >> | 36 | 2002 | R | 50 | 6 | 0 | 0 | 1 | 3.47 | .293 | 1.24 | 9.4 | 2.0 | 7.4 | 23.1 | 24 | 9 | 9 | 1 | 5 | 19 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2.57 |