| SP | deGrom, J.deGrom, Jacob $ >> | 33 | 2021 | R | 100 | 32 | 32 | 9 | 16 | 4.54 | .299 | 1.25 | 8.4 | 2.8 | 9.6 | 190.1 | 178 | 109 | 96 | 29 | 60 | 202 | 1 | 0 | 0 | 0 | 15 | 5 | 0 | 3.88 |
| SP | Santana, J.Santana, Johan $ >> | 25 | 2004 | L | 86 | 31 | 31 | 12 | 8 | 5.18 | .330 | 1.46 | 9.1 | 4.0 | 9.0 | 189.1 | 191 | 113 | 109 | 34 | 85 | 189 | 1 | 0 | 0 | 1 | 15 | 4 | 4 | 4.75 |
| SP | Hunter, C.Hunter, Catfish >> | 26 | 1972 | R | 81 | 31 | 31 | 10 | 11 | 5.44 | .313 | 1.32 | 8.9 | 3.1 | 5.2 | 193.2 | 190 | 119 | 117 | 29 | 66 | 111 | 5 | 0 | 0 | 1 | 13 | 9 | 4 | 4.97 |
| SP | Clemens, R.Clemens, Roger >> | 24 | 1986 | R | 69 | 30 | 29 | 10 | 9 | 5.37 | .324 | 1.42 | 8.8 | 3.9 | 5.4 | 179.1 | 176 | 117 | 107 | 31 | 78 | 108 | 5 | 0 | 0 | 0 | 13 | 4 | 7 | 5.42 |
| CL | Gagne, E.Gagne, Eric † >> | 27 | 2003 | R | 98 | 72 | 0 | 5 | 5 | 3.29 | .287 | 1.21 | 7.3 | 3.6 | 8.7 | 79.1 | 64 | 29 | 29 | 2 | 32 | 76 | 0 | 30 | 7 | 0 | 0 | 0 | 0 | 2.62 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 83 | 78 | 0 | 9 | 3 | 3.50 | .287 | 1.20 | 6.5 | 4.4 | 8.5 | 97.2 | 70 | 38 | 38 | 10 | 47 | 92 | 0 | 2 | 1 | 0 | 0 | 1 | 3 | 3.93 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 66 | 0 | 6 | 2 | 2.72 | .290 | 1.20 | 6.4 | 4.4 | 8.2 | 76.0 | 54 | 25 | 23 | 3 | 37 | 69 | 0 | 0 | 0 | 0 | 0 | 2 | 7 | 3.24 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 75 | 53 | 0 | 1 | 2 | 6.08 | .385 | 1.84 | 10.7 | 5.9 | 9.7 | 53.1 | 63 | 40 | 36 | 11 | 35 | 57 | 0 | 2 | 0 | 0 | 0 | 2 | 3 | 5.64 |
| SP | Greinke, Z.Greinke, Zack >> | 32 | 2015 | R | 94 | 21 | 0 | 4 | 3 | 2.98 | .256 | 1.03 | 6.2 | 3.2 | 6.9 | 48.1 | 33 | 16 | 16 | 5 | 17 | 37 | 0 | 3 | 0 | 0 | 0 | 0 | 2 | 3.88 |