| SP | Koufax, S.Koufax, Sandy † >> | 30 | 1965 | L | 97 | 32 | 32 | 18 | 7 | 3.26 | .286 | 1.18 | 7.7 | 3.0 | 8.0 | 237.2 | 203 | 90 | 86 | 21 | 78 | 211 | 5 | 0 | 0 | 2 | 24 | 4 | 6 | 3.41 |
| SP | Leonard, D.Leonard, Dutch $ >> | 22 | 1914 | L | 91 | 29 | 29 | 11 | 13 | 4.04 | .294 | 1.24 | 7.4 | 3.8 | 5.2 | 189.1 | 155 | 86 | 85 | 18 | 79 | 110 | 0 | 0 | 0 | 0 | 16 | 2 | 3 | 4.36 |
| SP | Johnson, R.Johnson, Randy # $$ >> | 41 | 2004 | L | 84 | 31 | 31 | 9 | 14 | 4.17 | .283 | 1.15 | 7.8 | 2.6 | 6.8 | 215.2 | 187 | 100 | 100 | 24 | 62 | 162 | 5 | 0 | 0 | 1 | 18 | 6 | 1 | 3.89 |
| SP | Adams, B.Adams, Babe # >> | 27 | 1909 | R | 86 | 29 | 29 | 11 | 9 | 5.06 | .318 | 1.38 | 9.5 | 2.9 | 4.7 | 162.0 | 171 | 95 | 91 | 20 | 52 | 85 | 0 | 0 | 0 | 0 | 14 | 4 | 5 | 4.59 |
| SP | Marichal, J.Marichal, Juan >> | 29 | 1966 | R | 77 | 28 | 28 | 9 | 14 | 6.55 | .345 | 1.56 | 11.0 | 3.1 | 5.5 | 180.0 | 220 | 131 | 131 | 37 | 61 | 110 | 5 | 0 | 0 | 0 | 7 | 4 | 4 | 5.53 |
| CL | Benoit, J.Benoit, Joaquin † >> | 33 | 2010 | R | 95 | 54 | 0 | 4 | 5 | 3.97 | .274 | 1.11 | 8.4 | 1.8 | 8.5 | 56.2 | 52 | 25 | 25 | 4 | 11 | 53 | 0 | 37 | 8 | 0 | 0 | 1 | 0 | 2.68 |
| SU | Gossage, R.Gossage, Rich $ >> | 30 | 1981 | R | 90 | 58 | 0 | 3 | 2 | 3.92 | .301 | 1.27 | 7.9 | 3.6 | 6.5 | 57.1 | 50 | 27 | 25 | 4 | 23 | 41 | 0 | 2 | 4 | 0 | 0 | 1 | 1 | 3.74 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 44 | 0 | 2 | 1 | 3.95 | .293 | 1.19 | 8.0 | 2.8 | 7.5 | 54.2 | 48 | 27 | 24 | 10 | 17 | 45 | 0 | 2 | 2 | 0 | 0 | 3 | 1 | 4.85 |
| RP | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 78 | 23 | 0 | 2 | 1 | 5.66 | .326 | 1.45 | 8.1 | 5.4 | 8.1 | 20.2 | 18 | 15 | 13 | 4 | 12 | 18 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 5.60 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 12 | 0 | 0 | 0 | 5.52 | .279 | 1.16 | 9.0 | 1.9 | 10.9 | 14.2 | 14 | 9 | 9 | 4 | 3 | 17 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.93 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 71 | 22 | 0 | 1 | 0 | 2.08 | .261 | 1.06 | 6.9 | 3.0 | 6.9 | 21.2 | 16 | 6 | 5 | 0 | 7 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2.48 |
| SP | Cueto, J.Cueto, Johnny >> | 28 | 2014 | R | 75 | 19 | 3 | 1 | 4 | 4.70 | .313 | 1.32 | 8.9 | 3.0 | 5.2 | 88.0 | 87 | 47 | 46 | 15 | 29 | 51 | 0 | 0 | 0 | 0 | 1 | 4 | 1 | 5.18 |