| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 27 | 27 | 13 | 7 | 2.93 | .249 | 0.98 | 6.3 | 2.5 | 10.1 | 172.0 | 121 | 58 | 56 | 13 | 47 | 193 | 1 | 0 | 0 | 1 | 18 | 3 | 0 | 2.61 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 92 | 27 | 27 | 7 | 11 | 4.83 | .304 | 1.28 | 9.0 | 2.6 | 7.6 | 154.2 | 154 | 89 | 83 | 22 | 44 | 130 | 0 | 0 | 0 | 0 | 11 | 5 | 7 | 4.12 |
| SP | Fernandez, J.Fernandez, Jose # >> | 21 | 2013 | R | 76 | 26 | 26 | 6 | 10 | 4.90 | .305 | 1.30 | 7.8 | 4.0 | 7.6 | 150.2 | 130 | 82 | 82 | 21 | 66 | 127 | 2 | 0 | 0 | 1 | 12 | 2 | 1 | 4.49 |
| RP | Kimbrel, C.Kimbrel, Craig † >> | 24 | 2012 | R | 100 | 70 | 0 | 6 | 1 | 1.52 | .239 | 0.92 | 4.9 | 3.5 | 9.6 | 100.2 | 54 | 19 | 17 | 4 | 39 | 107 | 0 | 11 | 6 | 0 | 0 | 2 | 6 | 2.61 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 84 | 50 | 0 | 3 | 1 | 2.09 | .233 | 0.91 | 5.5 | 2.8 | 9.4 | 51.2 | 31 | 12 | 12 | 3 | 16 | 53 | 0 | 13 | 2 | 0 | 0 | 0 | 2 | 2.63 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 28 | 0 | 1 | 2 | 3.40 | .217 | 0.83 | 4.6 | 3.0 | 6.7 | 39.2 | 20 | 15 | 15 | 3 | 13 | 29 | 0 | 5 | 0 | 0 | 0 | 0 | 4 | 3.51 |
| RP | Eichhorn, M.Eichhorn, Mark >> | 26 | 1986 | R | 49 | 26 | 0 | 5 | 4 | 3.09 | .277 | 1.12 | 6.4 | 3.6 | 6.4 | 67.0 | 48 | 23 | 23 | 6 | 27 | 48 | 0 | 1 | 0 | 0 | 0 | 2 | 2 | 4.03 |