| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 28 | 28 | 11 | 10 | 4.05 | .317 | 1.37 | 9.1 | 3.2 | 7.6 | 191.0 | 194 | 90 | 86 | 20 | 67 | 162 | 4 | 0 | 0 | 2 | 15 | 5 | 0 | 3.80 |
| SP | Maddux, G.Maddux, Greg $$ >> | 29 | 1995 | R | 89 | 28 | 28 | 16 | 6 | 3.79 | .296 | 1.24 | 9.3 | 1.9 | 5.2 | 201.2 | 208 | 90 | 85 | 16 | 43 | 117 | 3 | 0 | 0 | 1 | 17 | 3 | 6 | 3.56 |
| SP | Gibson, B.Gibson, Bob † >> | 33 | 1968 | R | 92 | 27 | 27 | 13 | 9 | 3.87 | .298 | 1.25 | 7.9 | 3.3 | 4.8 | 214.0 | 189 | 95 | 92 | 22 | 79 | 114 | 5 | 0 | 0 | 0 | 16 | 5 | 3 | 4.45 |
| SP | Martinez, P.Martinez, Pedro † $$ >> | 29 | 2000 | R | 100 | 27 | 27 | 13 | 5 | 3.99 | .289 | 1.22 | 8.3 | 2.6 | 7.6 | 194.0 | 179 | 93 | 86 | 23 | 57 | 164 | 5 | 0 | 0 | 2 | 13 | 1 | 4 | 3.75 |
| CL | Doolittle, S.Doolittle, Sean † >> | 31 | 2018 | L | 98 | 59 | 0 | 2 | 5 | 2.70 | .234 | 0.92 | 6.3 | 2.0 | 8.7 | 60.0 | 42 | 19 | 18 | 5 | 13 | 58 | 0 | 39 | 5 | 0 | 0 | 0 | 0 | 2.80 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 80 | 65 | 0 | 2 | 4 | 4.53 | .307 | 1.31 | 9.2 | 2.8 | 8.1 | 49.2 | 50 | 31 | 25 | 7 | 15 | 44 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 4.04 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 74 | 39 | 0 | 3 | 0 | 3.09 | .299 | 1.22 | 7.9 | 3.1 | 8.4 | 32.0 | 28 | 11 | 11 | 3 | 11 | 30 | 0 | 0 | 1 | 0 | 0 | 2 | 1 | 3.56 |
| SP | Bender, C.Bender, Chief >> | 26 | 1910 | R | 71 | 16 | 1 | 4 | 3 | 3.96 | .297 | 1.27 | 8.8 | 2.8 | 3.8 | 38.2 | 37 | 17 | 17 | 6 | 12 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.16 |